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Low mortality rates related to respiratory virus infections after bone marrow transplantation

Respiratory viruses (RVs) frequently cause severe respiratory disease in bone marrrow transplant (BMT) recipients. To evaluate the frequency of RV, nasal washes were collected year-round from BMT recipients with symptoms of upper respiratory tract infection (URI). Direct immunofluorescence assay was...

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Autores principales: Machado, C M, Boas, L S Vilas, Mendes, A V A, Santos, M F M, da Rocha, I F, Sturaro, D, Dulley, F L, Pannuti, C S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2003
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091922/
https://www.ncbi.nlm.nih.gov/pubmed/12692610
http://dx.doi.org/10.1038/sj.bmt.1703900
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author Machado, C M
Boas, L S Vilas
Mendes, A V A
Santos, M F M
da Rocha, I F
Sturaro, D
Dulley, F L
Pannuti, C S
author_facet Machado, C M
Boas, L S Vilas
Mendes, A V A
Santos, M F M
da Rocha, I F
Sturaro, D
Dulley, F L
Pannuti, C S
author_sort Machado, C M
collection PubMed
description Respiratory viruses (RVs) frequently cause severe respiratory disease in bone marrrow transplant (BMT) recipients. To evaluate the frequency of RV, nasal washes were collected year-round from BMT recipients with symptoms of upper respiratory tract infection (URI). Direct immunofluorescence assay was performed for respiratory syncytial virus (RSV), influenza (Flu) A and B, adenovirus and parainfluenza (Paraflu) virus. Patients with RSV pneumonia or with upper RSV infection, but considered at high risk for developing RSV pneumonia received aerosolized ribavirin. Oseltamivir was given to patients with influenza. A total of 179 patients had 392 episodes of URI. In all, 68 (38%) tested positive: RSV was detected in 18 patients (26.4%), Flu B in 17 (25%), Flu A in 11 (16.2%) and Paraflu in 7 (10.3%). A total of 14 patients (20.6%) had multiple RV infections or coinfection. RSV pneumonia developed in 55.5% of the patients with RSV-URI. One of the 15 patients (6.6%) with RSV pneumonia died. Influenza pneumonia was diagnosed in three patients (7.3%). RSV and influenza infections peaked in fall–winter and winter–spring months, respectively. We observed decreased rates of influenza and parainfluenza pneumonia and low mortality because of RSV pneumonia. The role of antiviral interventions such as aerosolized ribavirin and new neuraminidase inhibitors remains to be defined in randomized trials.
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spelling pubmed-70919222020-03-24 Low mortality rates related to respiratory virus infections after bone marrow transplantation Machado, C M Boas, L S Vilas Mendes, A V A Santos, M F M da Rocha, I F Sturaro, D Dulley, F L Pannuti, C S Bone Marrow Transplant Article Respiratory viruses (RVs) frequently cause severe respiratory disease in bone marrrow transplant (BMT) recipients. To evaluate the frequency of RV, nasal washes were collected year-round from BMT recipients with symptoms of upper respiratory tract infection (URI). Direct immunofluorescence assay was performed for respiratory syncytial virus (RSV), influenza (Flu) A and B, adenovirus and parainfluenza (Paraflu) virus. Patients with RSV pneumonia or with upper RSV infection, but considered at high risk for developing RSV pneumonia received aerosolized ribavirin. Oseltamivir was given to patients with influenza. A total of 179 patients had 392 episodes of URI. In all, 68 (38%) tested positive: RSV was detected in 18 patients (26.4%), Flu B in 17 (25%), Flu A in 11 (16.2%) and Paraflu in 7 (10.3%). A total of 14 patients (20.6%) had multiple RV infections or coinfection. RSV pneumonia developed in 55.5% of the patients with RSV-URI. One of the 15 patients (6.6%) with RSV pneumonia died. Influenza pneumonia was diagnosed in three patients (7.3%). RSV and influenza infections peaked in fall–winter and winter–spring months, respectively. We observed decreased rates of influenza and parainfluenza pneumonia and low mortality because of RSV pneumonia. The role of antiviral interventions such as aerosolized ribavirin and new neuraminidase inhibitors remains to be defined in randomized trials. Nature Publishing Group UK 2003-04-11 2003 /pmc/articles/PMC7091922/ /pubmed/12692610 http://dx.doi.org/10.1038/sj.bmt.1703900 Text en © Nature Publishing Group 2003 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Machado, C M
Boas, L S Vilas
Mendes, A V A
Santos, M F M
da Rocha, I F
Sturaro, D
Dulley, F L
Pannuti, C S
Low mortality rates related to respiratory virus infections after bone marrow transplantation
title Low mortality rates related to respiratory virus infections after bone marrow transplantation
title_full Low mortality rates related to respiratory virus infections after bone marrow transplantation
title_fullStr Low mortality rates related to respiratory virus infections after bone marrow transplantation
title_full_unstemmed Low mortality rates related to respiratory virus infections after bone marrow transplantation
title_short Low mortality rates related to respiratory virus infections after bone marrow transplantation
title_sort low mortality rates related to respiratory virus infections after bone marrow transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091922/
https://www.ncbi.nlm.nih.gov/pubmed/12692610
http://dx.doi.org/10.1038/sj.bmt.1703900
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