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RNAi, a new therapeutic strategy against viral infection
RNA interference (RNAi) is an adaptive defense mechanism triggered by double-stranded RNA (dsRNA). It is a powerful reverse genetic tool that has been widely employed to silence gene expression in mammalian and human cells. RNAi-based gene therapies, especially in viral diseases have become more and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2004
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092015/ https://www.ncbi.nlm.nih.gov/pubmed/15625012 http://dx.doi.org/10.1038/sj.cr.7290248 |
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author | TAN, Fischer L YIN, James Q |
author_facet | TAN, Fischer L YIN, James Q |
author_sort | TAN, Fischer L |
collection | PubMed |
description | RNA interference (RNAi) is an adaptive defense mechanism triggered by double-stranded RNA (dsRNA). It is a powerful reverse genetic tool that has been widely employed to silence gene expression in mammalian and human cells. RNAi-based gene therapies, especially in viral diseases have become more and more interesting and promising. Recently, small interfering RNA (siRNA) can be used to protect host from viral infection, inhibit the expression of viral antigen and accessory genes, control the transcription and replication of viral genome, hinder the assembly of viral particles, and display influences in virus-host interactions. In this review, we attempt to present recent progresses of this breakthrough technology in the above fields and summarize the possibilities of siRNA-based drugs. |
format | Online Article Text |
id | pubmed-7092015 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2004 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70920152020-03-24 RNAi, a new therapeutic strategy against viral infection TAN, Fischer L YIN, James Q Cell Res Article RNA interference (RNAi) is an adaptive defense mechanism triggered by double-stranded RNA (dsRNA). It is a powerful reverse genetic tool that has been widely employed to silence gene expression in mammalian and human cells. RNAi-based gene therapies, especially in viral diseases have become more and more interesting and promising. Recently, small interfering RNA (siRNA) can be used to protect host from viral infection, inhibit the expression of viral antigen and accessory genes, control the transcription and replication of viral genome, hinder the assembly of viral particles, and display influences in virus-host interactions. In this review, we attempt to present recent progresses of this breakthrough technology in the above fields and summarize the possibilities of siRNA-based drugs. Nature Publishing Group UK 2004-12 /pmc/articles/PMC7092015/ /pubmed/15625012 http://dx.doi.org/10.1038/sj.cr.7290248 Text en © Science Press 2004 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article TAN, Fischer L YIN, James Q RNAi, a new therapeutic strategy against viral infection |
title | RNAi, a new therapeutic strategy against viral infection |
title_full | RNAi, a new therapeutic strategy against viral infection |
title_fullStr | RNAi, a new therapeutic strategy against viral infection |
title_full_unstemmed | RNAi, a new therapeutic strategy against viral infection |
title_short | RNAi, a new therapeutic strategy against viral infection |
title_sort | rnai, a new therapeutic strategy against viral infection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092015/ https://www.ncbi.nlm.nih.gov/pubmed/15625012 http://dx.doi.org/10.1038/sj.cr.7290248 |
work_keys_str_mv | AT tanfischerl rnaianewtherapeuticstrategyagainstviralinfection AT yinjamesq rnaianewtherapeuticstrategyagainstviralinfection |