Cargando…

The primary cilium: Guardian of organ development and homeostasis

The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in...

Descripción completa

Detalles Bibliográficos
Autores principales: Fry, Andrew M, Leaper, Michelle J, Bayliss, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092719/
https://www.ncbi.nlm.nih.gov/pubmed/24743231
http://dx.doi.org/10.4161/org.28910
_version_ 1783510159150022656
author Fry, Andrew M
Leaper, Michelle J
Bayliss, Richard
author_facet Fry, Andrew M
Leaper, Michelle J
Bayliss, Richard
author_sort Fry, Andrew M
collection PubMed
description The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in terms of proliferation, differentiation, migration and polarization that ultimately lead to organ development and homeostasis. Defects in cilia function underlie a wide range of diverse but related human developmental or degenerative diseases. Collectively known as ciliopathies, these disorders present with varying severity and multiple organ involvement. The appreciation of the medical importance of the primary cilium has stimulated a huge effort into studies of the underlying cellular mechanisms. These in turn have revealed that ciliopathies result not only from defective assembly or organization of the primary cilium, but also from impaired ciliary signaling. This special edition of Organogenesis contains a set of review articles that highlight the role of the primary cilium in organ development and homeostasis, much of which has been learnt from studies of the associated human diseases. Here, we provide an introductory overview of our current understanding of the structure and function of the cilium, with a focus on the signaling pathways that are coordinated by primary cilia to ensure proper organ generation and maintenance.
format Online
Article
Text
id pubmed-7092719
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-70927192020-03-30 The primary cilium: Guardian of organ development and homeostasis Fry, Andrew M Leaper, Michelle J Bayliss, Richard Organogenesis Review The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in terms of proliferation, differentiation, migration and polarization that ultimately lead to organ development and homeostasis. Defects in cilia function underlie a wide range of diverse but related human developmental or degenerative diseases. Collectively known as ciliopathies, these disorders present with varying severity and multiple organ involvement. The appreciation of the medical importance of the primary cilium has stimulated a huge effort into studies of the underlying cellular mechanisms. These in turn have revealed that ciliopathies result not only from defective assembly or organization of the primary cilium, but also from impaired ciliary signaling. This special edition of Organogenesis contains a set of review articles that highlight the role of the primary cilium in organ development and homeostasis, much of which has been learnt from studies of the associated human diseases. Here, we provide an introductory overview of our current understanding of the structure and function of the cilium, with a focus on the signaling pathways that are coordinated by primary cilia to ensure proper organ generation and maintenance. Taylor & Francis 2014-04-17 2014-01-01 /pmc/articles/PMC7092719/ /pubmed/24743231 http://dx.doi.org/10.4161/org.28910 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Fry, Andrew M
Leaper, Michelle J
Bayliss, Richard
The primary cilium: Guardian of organ development and homeostasis
title The primary cilium: Guardian of organ development and homeostasis
title_full The primary cilium: Guardian of organ development and homeostasis
title_fullStr The primary cilium: Guardian of organ development and homeostasis
title_full_unstemmed The primary cilium: Guardian of organ development and homeostasis
title_short The primary cilium: Guardian of organ development and homeostasis
title_sort primary cilium: guardian of organ development and homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092719/
https://www.ncbi.nlm.nih.gov/pubmed/24743231
http://dx.doi.org/10.4161/org.28910
work_keys_str_mv AT fryandrewm theprimaryciliumguardianoforgandevelopmentandhomeostasis
AT leapermichellej theprimaryciliumguardianoforgandevelopmentandhomeostasis
AT baylissrichard theprimaryciliumguardianoforgandevelopmentandhomeostasis
AT fryandrewm primaryciliumguardianoforgandevelopmentandhomeostasis
AT leapermichellej primaryciliumguardianoforgandevelopmentandhomeostasis
AT baylissrichard primaryciliumguardianoforgandevelopmentandhomeostasis