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The primary cilium: Guardian of organ development and homeostasis
The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092719/ https://www.ncbi.nlm.nih.gov/pubmed/24743231 http://dx.doi.org/10.4161/org.28910 |
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author | Fry, Andrew M Leaper, Michelle J Bayliss, Richard |
author_facet | Fry, Andrew M Leaper, Michelle J Bayliss, Richard |
author_sort | Fry, Andrew M |
collection | PubMed |
description | The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in terms of proliferation, differentiation, migration and polarization that ultimately lead to organ development and homeostasis. Defects in cilia function underlie a wide range of diverse but related human developmental or degenerative diseases. Collectively known as ciliopathies, these disorders present with varying severity and multiple organ involvement. The appreciation of the medical importance of the primary cilium has stimulated a huge effort into studies of the underlying cellular mechanisms. These in turn have revealed that ciliopathies result not only from defective assembly or organization of the primary cilium, but also from impaired ciliary signaling. This special edition of Organogenesis contains a set of review articles that highlight the role of the primary cilium in organ development and homeostasis, much of which has been learnt from studies of the associated human diseases. Here, we provide an introductory overview of our current understanding of the structure and function of the cilium, with a focus on the signaling pathways that are coordinated by primary cilia to ensure proper organ generation and maintenance. |
format | Online Article Text |
id | pubmed-7092719 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-70927192020-03-30 The primary cilium: Guardian of organ development and homeostasis Fry, Andrew M Leaper, Michelle J Bayliss, Richard Organogenesis Review The primary cilium is an antenna-like organelle that plays a vital role in organ generation and maintenance. It protrudes from the cell surface where it receives signals from the surrounding environment and relays them into the cell. These signals are then integrated to give the required outputs in terms of proliferation, differentiation, migration and polarization that ultimately lead to organ development and homeostasis. Defects in cilia function underlie a wide range of diverse but related human developmental or degenerative diseases. Collectively known as ciliopathies, these disorders present with varying severity and multiple organ involvement. The appreciation of the medical importance of the primary cilium has stimulated a huge effort into studies of the underlying cellular mechanisms. These in turn have revealed that ciliopathies result not only from defective assembly or organization of the primary cilium, but also from impaired ciliary signaling. This special edition of Organogenesis contains a set of review articles that highlight the role of the primary cilium in organ development and homeostasis, much of which has been learnt from studies of the associated human diseases. Here, we provide an introductory overview of our current understanding of the structure and function of the cilium, with a focus on the signaling pathways that are coordinated by primary cilia to ensure proper organ generation and maintenance. Taylor & Francis 2014-04-17 2014-01-01 /pmc/articles/PMC7092719/ /pubmed/24743231 http://dx.doi.org/10.4161/org.28910 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Fry, Andrew M Leaper, Michelle J Bayliss, Richard The primary cilium: Guardian of organ development and homeostasis |
title | The primary cilium: Guardian of organ development and homeostasis |
title_full | The primary cilium: Guardian of organ development and homeostasis |
title_fullStr | The primary cilium: Guardian of organ development and homeostasis |
title_full_unstemmed | The primary cilium: Guardian of organ development and homeostasis |
title_short | The primary cilium: Guardian of organ development and homeostasis |
title_sort | primary cilium: guardian of organ development and homeostasis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092719/ https://www.ncbi.nlm.nih.gov/pubmed/24743231 http://dx.doi.org/10.4161/org.28910 |
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