A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes

BACKGROUND: There are several reports of seasonal variation in hemoglobin A1c (HbA1c) in patients with type 2 diabetes (T2DM), but no reports of seasonal variation in the effect of add-on drugs on blood glucose control in insulin-treated patients. METHODS: Using data collected from 630 patients in a...

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Autores principales: Takai, Masahiko, Ishikawa, Masashi, Maeda, Hajime, Kubota, Akira, Iemitsu, Kotaro, Umezawa, Shinichi, Kawata, Takehiro, Takuma, Tetsuo, Takeda, Hiroshi, Tanaka, Keiji, Machimura, Hideo, Minagawa, Fuyuki, Mokubo, Atsuko, Motomiya, Tetsuya, Kanamori, Akira, Matsuba, Ikuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092762/
https://www.ncbi.nlm.nih.gov/pubmed/32231757
http://dx.doi.org/10.14740/jocmr4103
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author Takai, Masahiko
Ishikawa, Masashi
Maeda, Hajime
Kubota, Akira
Iemitsu, Kotaro
Umezawa, Shinichi
Kawata, Takehiro
Takuma, Tetsuo
Takeda, Hiroshi
Tanaka, Keiji
Machimura, Hideo
Minagawa, Fuyuki
Mokubo, Atsuko
Motomiya, Tetsuya
Kanamori, Akira
Matsuba, Ikuro
author_facet Takai, Masahiko
Ishikawa, Masashi
Maeda, Hajime
Kubota, Akira
Iemitsu, Kotaro
Umezawa, Shinichi
Kawata, Takehiro
Takuma, Tetsuo
Takeda, Hiroshi
Tanaka, Keiji
Machimura, Hideo
Minagawa, Fuyuki
Mokubo, Atsuko
Motomiya, Tetsuya
Kanamori, Akira
Matsuba, Ikuro
author_sort Takai, Masahiko
collection PubMed
description BACKGROUND: There are several reports of seasonal variation in hemoglobin A1c (HbA1c) in patients with type 2 diabetes (T2DM), but no reports of seasonal variation in the effect of add-on drugs on blood glucose control in insulin-treated patients. METHODS: Using data collected from 630 patients in a multicenter study, we compared the amount of change in HbA1c after 1, 3, 6, 9, and 12 months of add-on administration of sitagliptin in insulin-treated patients divided into four groups based on the month when sitagliptin was started. RESULTS: A significantly larger decrease in HbA1c at 6 months from baseline was observed in the group that started add-on sitagliptin in February to April than in the other three groups. However, the amount of change in HbA1c at 12 months did not differ among the groups. CONCLUSIONS: The consideration of seasonal variation enables more accurate evaluation of a drug’s short-term effect on blood glucose control.
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spelling pubmed-70927622020-03-30 A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes Takai, Masahiko Ishikawa, Masashi Maeda, Hajime Kubota, Akira Iemitsu, Kotaro Umezawa, Shinichi Kawata, Takehiro Takuma, Tetsuo Takeda, Hiroshi Tanaka, Keiji Machimura, Hideo Minagawa, Fuyuki Mokubo, Atsuko Motomiya, Tetsuya Kanamori, Akira Matsuba, Ikuro J Clin Med Res Original Article BACKGROUND: There are several reports of seasonal variation in hemoglobin A1c (HbA1c) in patients with type 2 diabetes (T2DM), but no reports of seasonal variation in the effect of add-on drugs on blood glucose control in insulin-treated patients. METHODS: Using data collected from 630 patients in a multicenter study, we compared the amount of change in HbA1c after 1, 3, 6, 9, and 12 months of add-on administration of sitagliptin in insulin-treated patients divided into four groups based on the month when sitagliptin was started. RESULTS: A significantly larger decrease in HbA1c at 6 months from baseline was observed in the group that started add-on sitagliptin in February to April than in the other three groups. However, the amount of change in HbA1c at 12 months did not differ among the groups. CONCLUSIONS: The consideration of seasonal variation enables more accurate evaluation of a drug’s short-term effect on blood glucose control. Elmer Press 2020-03 2020-03-02 /pmc/articles/PMC7092762/ /pubmed/32231757 http://dx.doi.org/10.14740/jocmr4103 Text en Copyright 2020, Takai et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Takai, Masahiko
Ishikawa, Masashi
Maeda, Hajime
Kubota, Akira
Iemitsu, Kotaro
Umezawa, Shinichi
Kawata, Takehiro
Takuma, Tetsuo
Takeda, Hiroshi
Tanaka, Keiji
Machimura, Hideo
Minagawa, Fuyuki
Mokubo, Atsuko
Motomiya, Tetsuya
Kanamori, Akira
Matsuba, Ikuro
A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes
title A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes
title_full A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes
title_fullStr A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes
title_full_unstemmed A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes
title_short A Study of Seasonal Variation in the Effect of Add-On Sitagliptin on Blood Glucose Control in Insulin-Treated Patients With Type 2 Diabetes
title_sort study of seasonal variation in the effect of add-on sitagliptin on blood glucose control in insulin-treated patients with type 2 diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092762/
https://www.ncbi.nlm.nih.gov/pubmed/32231757
http://dx.doi.org/10.14740/jocmr4103
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