The nucleocapsid protein of SARS-associated coronavirus inhibits B23 phosphorylation

Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is responsible for SARS infection. Nucleocapsid (N) protein of SARS-CoV encapsidates the viral RNA and plays an important role in virus particle assembly and release. In this study, the N protein of SARS-CoV was found to associate w...

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Detalles Bibliográficos
Autores principales: Zeng, Yingchun, Ye, Linbai, Zhu, Shengli, Zheng, Hong, Zhao, Peng, Cai, Weijia, Su, Liya, She, Yinglong, Wu, Zhenghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Inc. 2008
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092856/
https://www.ncbi.nlm.nih.gov/pubmed/18243139
http://dx.doi.org/10.1016/j.bbrc.2008.01.096
Descripción
Sumario:Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is responsible for SARS infection. Nucleocapsid (N) protein of SARS-CoV encapsidates the viral RNA and plays an important role in virus particle assembly and release. In this study, the N protein of SARS-CoV was found to associate with B23, a phosphoprotein in nucleolus, in vitro and in vivo. Mapping studies localized the critical N sequences for this interaction to amino acid residues 175–210, which included a serine/arginine (SR)-rich domain. In vitro phosphorylation assay showed that the N protein inhibited the B23 phosphorylation at Thr199.

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