Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes

Microsatellites (SSRs) are ubiquitous in coding and non-coding regions of the Ebolavirus genomes. We synthetically analyzed the microsatellites in whole-genome and terminal regions of 219 Ebolavirus genomes from five species. The Ebolavirus sequences were observed with small intraspecies variations...

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Autores principales: Li, Douyue, Zhang, Hongxi, Peng, Shan, Pan, Saichao, Tan, Zhongyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092875/
https://www.ncbi.nlm.nih.gov/pubmed/31078274
http://dx.doi.org/10.1016/j.bbrc.2019.04.192
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author Li, Douyue
Zhang, Hongxi
Peng, Shan
Pan, Saichao
Tan, Zhongyang
author_facet Li, Douyue
Zhang, Hongxi
Peng, Shan
Pan, Saichao
Tan, Zhongyang
author_sort Li, Douyue
collection PubMed
description Microsatellites (SSRs) are ubiquitous in coding and non-coding regions of the Ebolavirus genomes. We synthetically analyzed the microsatellites in whole-genome and terminal regions of 219 Ebolavirus genomes from five species. The Ebolavirus sequences were observed with small intraspecies variations and large interspecific variations, especially in the terminal non-coding regions. Only five conserved microsatellites were detected in the complete genomes, and four of them which well base-paired to help forming conserved stem-loop structures mainly appeared in the terminal non-coding regions. These results suggest that the conserved microsatellites may be evolutionary selected to form conserved secondary structures in 5′, 3′ terminals of Ebolavirus genomes. It may help to understand the biological significance of microsatellites in Ebolavirus and also other virus genomes.
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spelling pubmed-70928752020-03-25 Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes Li, Douyue Zhang, Hongxi Peng, Shan Pan, Saichao Tan, Zhongyang Biochem Biophys Res Commun Article Microsatellites (SSRs) are ubiquitous in coding and non-coding regions of the Ebolavirus genomes. We synthetically analyzed the microsatellites in whole-genome and terminal regions of 219 Ebolavirus genomes from five species. The Ebolavirus sequences were observed with small intraspecies variations and large interspecific variations, especially in the terminal non-coding regions. Only five conserved microsatellites were detected in the complete genomes, and four of them which well base-paired to help forming conserved stem-loop structures mainly appeared in the terminal non-coding regions. These results suggest that the conserved microsatellites may be evolutionary selected to form conserved secondary structures in 5′, 3′ terminals of Ebolavirus genomes. It may help to understand the biological significance of microsatellites in Ebolavirus and also other virus genomes. Elsevier Inc. 2019-06-30 2019-05-08 /pmc/articles/PMC7092875/ /pubmed/31078274 http://dx.doi.org/10.1016/j.bbrc.2019.04.192 Text en © 2019 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Li, Douyue
Zhang, Hongxi
Peng, Shan
Pan, Saichao
Tan, Zhongyang
Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
title Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
title_full Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
title_fullStr Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
title_full_unstemmed Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
title_short Conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of Ebolavirus genomes
title_sort conserved microsatellites may contribute to stem-loop structures in 5′, 3′ terminals of ebolavirus genomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092875/
https://www.ncbi.nlm.nih.gov/pubmed/31078274
http://dx.doi.org/10.1016/j.bbrc.2019.04.192
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