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Rational design of highly potent HIV-1 fusion inhibitory proteins: Implication for developing antiviral therapeutics

Recombinant protein containing one heptad-repeat 1 (HR1) segment and one HR2 segment of the HIV-1 gp41 (HR1–HR2) has been shown to fold into thermally stable six-helix bundle, representing the fusogenic core of gp41. In this study, we have used the fusogenic core as a scaffold to design HIV-1 fusion...

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Detalles Bibliográficos
Autores principales:	Ni, Ling, Gao, George F., Tien, Po
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092902/ https://www.ncbi.nlm.nih.gov/pubmed/15913557 http://dx.doi.org/10.1016/j.bbrc.2005.05.037

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