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Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease

SARS-CoV 3CL protease is essential for viral protein processing and is regarded as a good drug target to prevent SARS-CoV replication. In the present study, we established a high-throughput FRET technique for screening for anti-SARS-CoV 3CL protease drugs. Of a thousand existing drugs examined, hexa...

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Detalles Bibliográficos
Autores principales:	Liu, Yu-Chih, Huang, Vicky, Chao, Ti-Chun, Hsiao, Chwan-Deng, Lin, Atsui, Chang, Ming-Fu, Chow, Lu-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Inc. 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092914/ https://www.ncbi.nlm.nih.gov/pubmed/15950190 http://dx.doi.org/10.1016/j.bbrc.2005.05.095

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