Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics

The current pandemic influenza A (H1N1) virus has revealed a complicated reassortment of various influenza A viruses. The biological study of these viruses, especially of the viral envelope proteins hemagglutinin (HA) and neuraminidase (NA), is urgently needed for the control and prevention of H1N1...

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Autores principales: Zhang, Yonghui, Lin, Xiaojing, Zhang, Fengwei, Wu, Jia, Tan, Wenjie, Bi, Shengli, Zhou, Jianfang, Shu, Yuelong, Wang, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092934/
https://www.ncbi.nlm.nih.gov/pubmed/19615337
http://dx.doi.org/10.1016/j.bbrc.2009.07.040
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author Zhang, Yonghui
Lin, Xiaojing
Zhang, Fengwei
Wu, Jia
Tan, Wenjie
Bi, Shengli
Zhou, Jianfang
Shu, Yuelong
Wang, Yue
author_facet Zhang, Yonghui
Lin, Xiaojing
Zhang, Fengwei
Wu, Jia
Tan, Wenjie
Bi, Shengli
Zhou, Jianfang
Shu, Yuelong
Wang, Yue
author_sort Zhang, Yonghui
collection PubMed
description The current pandemic influenza A (H1N1) virus has revealed a complicated reassortment of various influenza A viruses. The biological study of these viruses, especially of the viral envelope proteins hemagglutinin (HA) and neuraminidase (NA), is urgently needed for the control and prevention of H1N1 viruses. We have generated H1N1-2009 and H1N1-1918 pseudotyped particles (pp) with high infectivity. Combinations of HA1918 + NA2009 and HA2009 + NA1918 also formed infectious H1N1pps, among which the HA2009 + NA1918 combination resulted in the most highly infectious pp. Our study demonstrated that some reassortments of H1N1 viruses may hold the potential to produce higher infectivity than do their ancestors.
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spelling pubmed-70929342020-03-25 Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics Zhang, Yonghui Lin, Xiaojing Zhang, Fengwei Wu, Jia Tan, Wenjie Bi, Shengli Zhou, Jianfang Shu, Yuelong Wang, Yue Biochem Biophys Res Commun Article The current pandemic influenza A (H1N1) virus has revealed a complicated reassortment of various influenza A viruses. The biological study of these viruses, especially of the viral envelope proteins hemagglutinin (HA) and neuraminidase (NA), is urgently needed for the control and prevention of H1N1 viruses. We have generated H1N1-2009 and H1N1-1918 pseudotyped particles (pp) with high infectivity. Combinations of HA1918 + NA2009 and HA2009 + NA1918 also formed infectious H1N1pps, among which the HA2009 + NA1918 combination resulted in the most highly infectious pp. Our study demonstrated that some reassortments of H1N1 viruses may hold the potential to produce higher infectivity than do their ancestors. Elsevier Inc. 2009-09-18 2009-07-15 /pmc/articles/PMC7092934/ /pubmed/19615337 http://dx.doi.org/10.1016/j.bbrc.2009.07.040 Text en Copyright © 2009 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Zhang, Yonghui
Lin, Xiaojing
Zhang, Fengwei
Wu, Jia
Tan, Wenjie
Bi, Shengli
Zhou, Jianfang
Shu, Yuelong
Wang, Yue
Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics
title Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics
title_full Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics
title_fullStr Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics
title_full_unstemmed Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics
title_short Hemagglutinin and neuraminidase matching patterns of two influenza A virus strains related to the 1918 and 2009 global pandemics
title_sort hemagglutinin and neuraminidase matching patterns of two influenza a virus strains related to the 1918 and 2009 global pandemics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092934/
https://www.ncbi.nlm.nih.gov/pubmed/19615337
http://dx.doi.org/10.1016/j.bbrc.2009.07.040
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