Prediction of quaternary assembly of SARS coronavirus peplomer

The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is sugge...

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Autores principales: Bernini, Andrea, Spiga, Ottavia, Ciutti, Arianna, Chiellini, Stefano, Bracci, Luisa, Yan, Xiyun, Zheng, Bojian, Huang, Jiandong, He, Ming-Liang, Song, Huai-Dong, Hao, Pei, Zhao, Guoping, Niccolai, Neri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2004
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092937/
https://www.ncbi.nlm.nih.gov/pubmed/15555555
http://dx.doi.org/10.1016/j.bbrc.2004.10.156
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author Bernini, Andrea
Spiga, Ottavia
Ciutti, Arianna
Chiellini, Stefano
Bracci, Luisa
Yan, Xiyun
Zheng, Bojian
Huang, Jiandong
He, Ming-Liang
Song, Huai-Dong
Hao, Pei
Zhao, Guoping
Niccolai, Neri
author_facet Bernini, Andrea
Spiga, Ottavia
Ciutti, Arianna
Chiellini, Stefano
Bracci, Luisa
Yan, Xiyun
Zheng, Bojian
Huang, Jiandong
He, Ming-Liang
Song, Huai-Dong
Hao, Pei
Zhao, Guoping
Niccolai, Neri
author_sort Bernini, Andrea
collection PubMed
description The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections.
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spelling pubmed-70929372020-03-25 Prediction of quaternary assembly of SARS coronavirus peplomer Bernini, Andrea Spiga, Ottavia Ciutti, Arianna Chiellini, Stefano Bracci, Luisa Yan, Xiyun Zheng, Bojian Huang, Jiandong He, Ming-Liang Song, Huai-Dong Hao, Pei Zhao, Guoping Niccolai, Neri Biochem Biophys Res Commun Article The tertiary structures of the S1 and S2 domains of the spike protein of the coronavirus which is responsible of the severe acute respiratory syndrome (SARS) have been recently predicted. Here a molecular assembly of SARS coronavirus peplomer which accounts for the available functional data is suggested. The interaction between S1 and S2 appears to be stabilised by a large hydrophobic network of aromatic side chains present in both domains. This feature results to be common to all coronaviruses, suggesting potential targeting for drugs preventing coronavirus-related infections. Elsevier Inc. 2004-12-24 2004-11-11 /pmc/articles/PMC7092937/ /pubmed/15555555 http://dx.doi.org/10.1016/j.bbrc.2004.10.156 Text en Copyright © 2004 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bernini, Andrea
Spiga, Ottavia
Ciutti, Arianna
Chiellini, Stefano
Bracci, Luisa
Yan, Xiyun
Zheng, Bojian
Huang, Jiandong
He, Ming-Liang
Song, Huai-Dong
Hao, Pei
Zhao, Guoping
Niccolai, Neri
Prediction of quaternary assembly of SARS coronavirus peplomer
title Prediction of quaternary assembly of SARS coronavirus peplomer
title_full Prediction of quaternary assembly of SARS coronavirus peplomer
title_fullStr Prediction of quaternary assembly of SARS coronavirus peplomer
title_full_unstemmed Prediction of quaternary assembly of SARS coronavirus peplomer
title_short Prediction of quaternary assembly of SARS coronavirus peplomer
title_sort prediction of quaternary assembly of sars coronavirus peplomer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092937/
https://www.ncbi.nlm.nih.gov/pubmed/15555555
http://dx.doi.org/10.1016/j.bbrc.2004.10.156
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