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Operation of mitochondrial machinery in viral infection-induced immune responses

Mitochondria have been recognized as ancient bacteria that contain evolutionary endosymbionts. Metabolic pathways and inflammatory signals interact within mitochondria in response to different stresses, such as viral infections. In this commentary, we address several interesting questions, including...

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Detalles Bibliográficos
Autores principales: Lai, Jenn-Haung, Luo, Shue-Fen, Ho, Ling-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092938/
https://www.ncbi.nlm.nih.gov/pubmed/30172712
http://dx.doi.org/10.1016/j.bcp.2018.08.044
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author Lai, Jenn-Haung
Luo, Shue-Fen
Ho, Ling-Jun
author_facet Lai, Jenn-Haung
Luo, Shue-Fen
Ho, Ling-Jun
author_sort Lai, Jenn-Haung
collection PubMed
description Mitochondria have been recognized as ancient bacteria that contain evolutionary endosymbionts. Metabolic pathways and inflammatory signals interact within mitochondria in response to different stresses, such as viral infections. In this commentary, we address several interesting questions, including (1) how do mitochondrial machineries participate in immune responses; (2) how do mitochondria mediate antiviral immunity; (3) what mechanisms involved in mitochondrial machinery, including the downregulation of mitochondrial DNA (mtDNA), disturbances of mitochondrial dynamics, and the induction of mitophagy and regulation of apoptosis, have been adopted by viruses to evade antiviral immunity; (4) what mechanisms involve the regulation of mitochondrial machineries in antiviral therapeutics; and (5) what are the potential challenges and perspectives in developing mitochondria-targeting antiviral treatments? This commentary provides a comprehensive review of the roles and mechanisms of mitochondrial machineries in immunity, viral infections and related antiviral therapeutics.
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spelling pubmed-70929382020-03-25 Operation of mitochondrial machinery in viral infection-induced immune responses Lai, Jenn-Haung Luo, Shue-Fen Ho, Ling-Jun Biochem Pharmacol Commentary Mitochondria have been recognized as ancient bacteria that contain evolutionary endosymbionts. Metabolic pathways and inflammatory signals interact within mitochondria in response to different stresses, such as viral infections. In this commentary, we address several interesting questions, including (1) how do mitochondrial machineries participate in immune responses; (2) how do mitochondria mediate antiviral immunity; (3) what mechanisms involved in mitochondrial machinery, including the downregulation of mitochondrial DNA (mtDNA), disturbances of mitochondrial dynamics, and the induction of mitophagy and regulation of apoptosis, have been adopted by viruses to evade antiviral immunity; (4) what mechanisms involve the regulation of mitochondrial machineries in antiviral therapeutics; and (5) what are the potential challenges and perspectives in developing mitochondria-targeting antiviral treatments? This commentary provides a comprehensive review of the roles and mechanisms of mitochondrial machineries in immunity, viral infections and related antiviral therapeutics. Elsevier Inc. 2018-10 2018-08-31 /pmc/articles/PMC7092938/ /pubmed/30172712 http://dx.doi.org/10.1016/j.bcp.2018.08.044 Text en © 2018 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Commentary
Lai, Jenn-Haung
Luo, Shue-Fen
Ho, Ling-Jun
Operation of mitochondrial machinery in viral infection-induced immune responses
title Operation of mitochondrial machinery in viral infection-induced immune responses
title_full Operation of mitochondrial machinery in viral infection-induced immune responses
title_fullStr Operation of mitochondrial machinery in viral infection-induced immune responses
title_full_unstemmed Operation of mitochondrial machinery in viral infection-induced immune responses
title_short Operation of mitochondrial machinery in viral infection-induced immune responses
title_sort operation of mitochondrial machinery in viral infection-induced immune responses
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092938/
https://www.ncbi.nlm.nih.gov/pubmed/30172712
http://dx.doi.org/10.1016/j.bcp.2018.08.044
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