Genetic compensation in a stable slc25a46 mutant zebrafish: A case for using F0 CRISPR mutagenesis to study phenotypes caused by inherited disease

A phenomenon of genetic compensation is commonly observed when an organism with a disease-bearing mutation shows incomplete penetrance of the disease phenotype. Such incomplete phenotypic penetrance, or genetic compensation, is more commonly found in stable knockout models, rather than transient kno...

Descripción completa

Detalles Bibliográficos
Autores principales: Buglo, Elena, Sarmiento, Evan, Martuscelli, Nicole Belliard, Sant, David W., Danzi, Matt C., Abrams, Alexander J., Dallman, Julia E., Züchner, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092968/
https://www.ncbi.nlm.nih.gov/pubmed/32208444
http://dx.doi.org/10.1371/journal.pone.0230566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092968/
https://www.ncbi.nlm.nih.gov/pubmed/32208444
http://dx.doi.org/10.1371/journal.pone.0230566

Ejemplares similares