Cargando…
Diverse Role of TGF-β in Kidney Disease
Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD). Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal fibrosis. In addition, TGF-β also acts as a potent anti-inflammatory cytokine that negatively regulates renal inflammation...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093020/ https://www.ncbi.nlm.nih.gov/pubmed/32258028 http://dx.doi.org/10.3389/fcell.2020.00123 |
_version_ | 1783510218708090880 |
---|---|
author | Gu, Yue-Yu Liu, Xu-Sheng Huang, Xiao-Ru Yu, Xue-Qing Lan, Hui-Yao |
author_facet | Gu, Yue-Yu Liu, Xu-Sheng Huang, Xiao-Ru Yu, Xue-Qing Lan, Hui-Yao |
author_sort | Gu, Yue-Yu |
collection | PubMed |
description | Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD). Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal fibrosis. In addition, TGF-β also acts as a potent anti-inflammatory cytokine that negatively regulates renal inflammation. Thus, blockade of TGF-β inhibits renal fibrosis while promoting inflammation, revealing a diverse role for TGF-β in CKD. It is now well documented that TGF-β1 activates its downstream signaling molecules such as Smad3 and Smad3-dependent non-coding RNAs to transcriptionally and differentially regulate renal inflammation and fibrosis, which is negatively regulated by Smad7. Therefore, treatments by rebalancing Smad3/Smad7 signaling or by specifically targeting Smad3-dependent non-coding RNAs that regulate renal fibrosis or inflammation could be a better therapeutic approach. In this review, the paradoxical functions and underlying mechanisms by which TGF-β1 regulates in renal inflammation and fibrosis are discussed and novel therapeutic strategies for kidney disease by targeting downstream TGF-β/Smad signaling and transcriptomes are highlighted. |
format | Online Article Text |
id | pubmed-7093020 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70930202020-03-31 Diverse Role of TGF-β in Kidney Disease Gu, Yue-Yu Liu, Xu-Sheng Huang, Xiao-Ru Yu, Xue-Qing Lan, Hui-Yao Front Cell Dev Biol Cell and Developmental Biology Inflammation and fibrosis are two pathological features of chronic kidney disease (CKD). Transforming growth factor-β (TGF-β) has been long considered as a key mediator of renal fibrosis. In addition, TGF-β also acts as a potent anti-inflammatory cytokine that negatively regulates renal inflammation. Thus, blockade of TGF-β inhibits renal fibrosis while promoting inflammation, revealing a diverse role for TGF-β in CKD. It is now well documented that TGF-β1 activates its downstream signaling molecules such as Smad3 and Smad3-dependent non-coding RNAs to transcriptionally and differentially regulate renal inflammation and fibrosis, which is negatively regulated by Smad7. Therefore, treatments by rebalancing Smad3/Smad7 signaling or by specifically targeting Smad3-dependent non-coding RNAs that regulate renal fibrosis or inflammation could be a better therapeutic approach. In this review, the paradoxical functions and underlying mechanisms by which TGF-β1 regulates in renal inflammation and fibrosis are discussed and novel therapeutic strategies for kidney disease by targeting downstream TGF-β/Smad signaling and transcriptomes are highlighted. Frontiers Media S.A. 2020-02-28 /pmc/articles/PMC7093020/ /pubmed/32258028 http://dx.doi.org/10.3389/fcell.2020.00123 Text en Copyright © 2020 Gu, Liu, Huang, Yu and Lan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Gu, Yue-Yu Liu, Xu-Sheng Huang, Xiao-Ru Yu, Xue-Qing Lan, Hui-Yao Diverse Role of TGF-β in Kidney Disease |
title | Diverse Role of TGF-β in Kidney Disease |
title_full | Diverse Role of TGF-β in Kidney Disease |
title_fullStr | Diverse Role of TGF-β in Kidney Disease |
title_full_unstemmed | Diverse Role of TGF-β in Kidney Disease |
title_short | Diverse Role of TGF-β in Kidney Disease |
title_sort | diverse role of tgf-β in kidney disease |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093020/ https://www.ncbi.nlm.nih.gov/pubmed/32258028 http://dx.doi.org/10.3389/fcell.2020.00123 |
work_keys_str_mv | AT guyueyu diverseroleoftgfbinkidneydisease AT liuxusheng diverseroleoftgfbinkidneydisease AT huangxiaoru diverseroleoftgfbinkidneydisease AT yuxueqing diverseroleoftgfbinkidneydisease AT lanhuiyao diverseroleoftgfbinkidneydisease |