The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques

Despite the success of antiretroviral therapy (ART) to halt viral replication and slow disease progression, this treatment is not curative and there remains an urgent need to develop approaches to clear the latent HIV reservoir. The human IL-15 superagonist N-803 (formerly ALT-803) is a promising an...

Descripción completa

Detalles Bibliográficos
Autores principales: Webb, Gabriela M., Molden, Jhomary, Busman-Sahay, Kathleen, Abdulhaqq, Shaheed, Wu, Helen L., Weber, Whitney C., Bateman, Katherine B., Reed, Jason S., Northrup, Mina, Maier, Nicholas, Tanaka, Shiho, Gao, Lina, Davey, Brianna, Carpenter, Benjamin L., Axthelm, Michael K., Stanton, Jeffrey J., Smedley, Jeremy, Greene, Justin M., Safrit, Jeffrey T., Estes, Jacob D., Skinner, Pamela J., Sacha, Jonah B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093032/
https://www.ncbi.nlm.nih.gov/pubmed/32163523
http://dx.doi.org/10.1371/journal.ppat.1008339

Ejemplares similares

Ejemplares similares