Cargando…

HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

Parkinson's disease (PD) is a progressive neurodegenerative disorder. A common and disabling disease of the elderly, the standard dopamine replacement therapies do not arrest the ongoing neurodegeneration, thus calling for new treatment strategies. The present study aimed to clarify the functio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Guangping, Chen, Luzhu, Liu, Jing, Jin, Yan, Lin, Zaihong, Du, Shu, Fu, Zenghui, Chen, Tuantuan, Qin, Yinghui, Sui, Fenghu, Jiang, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093183/ https://www.ncbi.nlm.nih.gov/pubmed/32167488 http://dx.doi.org/10.18632/aging.102636

Ejemplares similares

Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway
por: Chen, Lianqi, et al.
Publicado: (2023)

SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway
por: Wang, Yuting, et al.
Publicado: (2022)

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression
por: Peng, Yin, et al.
Publicado: (2021)

Expression of β-catenin and AXIN2 in ameloblastomas
por: Wei, Zhenhui, et al.
Publicado: (2013)

The SIAH E3 ubiquitin ligases promote Wnt/β-catenin signaling through mediating Wnt-induced Axin degradation
por: Ji, Lei, et al.
Publicado: (2017)

Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction
por: Kan, Wei, et al.
Publicado: (2020)

Bili Inhibits Wnt/β-Catenin Signaling by Regulating the Recruitment of Axin to LRP6
por: Kategaya, Lorna S., et al.
Publicado: (2009)

USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin
por: Ji, Lei, et al.
Publicado: (2019)

Wnt/Axin1/β-Catenin Signaling Regulates Asymmetric Nodal Activation, Elaboration, and Concordance of CNS Asymmetries
por: Carl, Matthias, et al.
Publicado: (2007)

Targeting TRIM54/Axin1/β-Catenin Axis Prohibits Proliferation and Metastasis in Hepatocellular Carcinoma
por: Zhu, Jinrong, et al.
Publicado: (2021)

Differential Roles of AXIN1 and AXIN2 in Tankyrase Inhibitor-Induced Formation of Degradasomes and β-Catenin Degradation
por: Thorvaldsen, Tor Espen, et al.
Publicado: (2017)

TRIM37 promotes gallbladder cancer proliferation by activating the Wnt/β-catenin pathway via ubiquitination of Axin1
por: Xu, Ming, et al.
Publicado: (2023)

USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/β‐catenin pathway via Axin1 deubiquitination
por: Huang, Tong, et al.
Publicado: (2020)

WNT/β-catenin pathway activation via Wnt1 overexpression and Axin1 downregulation correlates with cadherin-catenin complex disruption and increased lymph node involvement in micropapillary-predominant lung adenocarcinoma
por: Zhu, Liang, et al.
Publicado: (2020)

An aggregon in conductin/axin2 regulates Wnt/β-catenin signaling and holds potential for cancer therapy
por: Bernkopf, Dominic B., et al.
Publicado: (2019)

Curcumin suppresses colorectal tumorigenesis via the Wnt/β-catenin signaling pathway by downregulating Axin2
por: Hao, Jiaxue, et al.
Publicado: (2021)

Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear β-catenin expression
por: Koppert, L B, et al.
Publicado: (2004)

miR-103/107 prolong Wnt/β-catenin signaling and colorectal cancer stemness by targeting Axin2
por: Chen, Hsin-Yi, et al.
Publicado: (2019)

C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling
por: Jiang, Jun, et al.
Publicado: (2018)

Phase separation of Axin organizes the β-catenin destruction complex
por: Nong, Junxiu, et al.
Publicado: (2021)

SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer
por: Liu, Huidi, et al.
Publicado: (2016)

RNA m(6)A reader YTHDF2 facilitates lung adenocarcinoma cell proliferation and metastasis by targeting the AXIN1/Wnt/β-catenin signaling
por: Li, Yin, et al.
Publicado: (2021)

Tankyrase Inhibitors Stimulate the Ability of Tankyrases to Bind Axin and Drive Assembly of β-Catenin Degradation-Competent Axin Puncta
por: Martino-Echarri, Estefania, et al.
Publicado: (2016)

WDR26 is a new partner of Axin1 in the canonical Wnt signaling pathway
por: Goto, Toshiyasu, et al.
Publicado: (2016)

CCAAT/enhancer-binding protein-β functions as a negative regulator of Wnt/β-catenin signaling through activation of AXIN1 gene expression
por: Park, Seoyoung, et al.
Publicado: (2018)

Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling
por: Wang, Zhenghan, et al.
Publicado: (2016)

Axin2-expressing cells differentiate into reparative odontoblasts via autocrine Wnt/β-catenin signaling in response to tooth damage
por: Babb, Rebecca, et al.
Publicado: (2017)

UCHL5 controls β-catenin destruction complex function through Axin1 regulation
por: Han, Wonhee, et al.
Publicado: (2022)

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC
por: Tacchelly-Benites, Ofelia, et al.
Publicado: (2018)

Inhibition of Tankyrases Induces Axin Stabilization and Blocks Wnt Signalling in Breast Cancer Cells
por: Bao, Renyue, et al.
Publicado: (2012)

LGALS3 and AXIN1 gene variants playing role in the Wnt/β-catenin signaling pathway are associated with mucinous component and tumor size in colorectal cancer
por: Korkmaz, Gurbet, et al.
Publicado: (2016)

The E3 Ubiquitin Ligase TRIM11 Facilitates Gastric Cancer Progression by Activating the Wnt/β-Catenin Pathway via Destabilizing Axin1 Protein
por: Zhou, Ling, et al.
Publicado: (2022)

Tripartite motif 31 drives gastric cancer cell proliferation and invasion through activating the Wnt/β-catenin pathway by regulating Axin1 protein stability
por: Feng, Qi, et al.
Publicado: (2023)

Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect
por: Chen, Wei-Wei, et al.
Publicado: (2019)

Protective effect of edaravone on blood-brain barrier by affecting NRF-2/HO-1 signaling pathway
por: Liu, Jing, et al.
Publicado: (2019)

Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth
por: Miete, Cezanne, et al.
Publicado: (2022)

Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice
por: Xie, Rong, et al.
Publicado: (2022)

New insights into the regulation of Axin function in canonical Wnt signaling pathway
por: Song, Xiaomin, et al.
Publicado: (2014)

Targeting the NAD(+) salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level
por: Ye, Chenyang, et al.
Publicado: (2020)

5-hydroxytryptamine receptor (5-HT(1D)R) promotes colorectal cancer metastasis by regulating Axin1/β-catenin/MMP-7 signaling pathway
por: Sui, Hua, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_73g8pa4s1n7ibkcv4d42r0hc1t