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Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome

Although many studies have focused on functional impairment after intracerebral hemorrhage, little is known about the relationship between secondary injuries to distal regions and neurological function. Our study aimed to evaluate the secondary injuries after intracerebral hemorrhage and explore the...

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Autores principales: Song, Kangping, Liu, Xiaojie, Zheng, Qiuyue, Zhang, Lingling, Zhang, Hongying, Yu, Hailong, Zhu, Yan, Huang, Li-An, Chen, Yingzhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093199/
https://www.ncbi.nlm.nih.gov/pubmed/32146443
http://dx.doi.org/10.18632/aging.102880
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author Song, Kangping
Liu, Xiaojie
Zheng, Qiuyue
Zhang, Lingling
Zhang, Hongying
Yu, Hailong
Zhu, Yan
Huang, Li-An
Chen, Yingzhu
author_facet Song, Kangping
Liu, Xiaojie
Zheng, Qiuyue
Zhang, Lingling
Zhang, Hongying
Yu, Hailong
Zhu, Yan
Huang, Li-An
Chen, Yingzhu
author_sort Song, Kangping
collection PubMed
description Although many studies have focused on functional impairment after intracerebral hemorrhage, little is known about the relationship between secondary injuries to distal regions and neurological function. Our study aimed to evaluate the secondary injuries after intracerebral hemorrhage and explore their relationship to neurological functional outcome. Twenty-one patients with hemorrhages in supratentorial, deep locations and 10 healthy subjects were recruited. Longitudinal examinations of diffusion tensor imaging, hydrogen proton magnetic resonance spectroscopy imaging and neuropsychological assessment were performed after weeks 1 and 12 to elucidate the relationship between magnetic resonance imaging parameters and neurologic outcomes. By week 12, motor function had significantly improved, but cognitive function had deteriorated compared to week 1. Fractional anisotropy values for the ipsilateral cerebral peduncle correlated with motor function at week 1. No significant correlation between fractional anisotropy for the ipsilateral cerebral peduncle and the Fugl-Meyer Motor Scale was found at week 12. Fractional anisotropy values for the ipsilateral hippocampus were related to the Montreal Cognitive Assessment and Mini-Mental State Examination at weeks 1 and 12. Deep supratentorial hemorrhage may result in injury to distal regions, which correlate with impaired motor and cognitive function.
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spelling pubmed-70931992020-03-30 Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome Song, Kangping Liu, Xiaojie Zheng, Qiuyue Zhang, Lingling Zhang, Hongying Yu, Hailong Zhu, Yan Huang, Li-An Chen, Yingzhu Aging (Albany NY) Research Paper Although many studies have focused on functional impairment after intracerebral hemorrhage, little is known about the relationship between secondary injuries to distal regions and neurological function. Our study aimed to evaluate the secondary injuries after intracerebral hemorrhage and explore their relationship to neurological functional outcome. Twenty-one patients with hemorrhages in supratentorial, deep locations and 10 healthy subjects were recruited. Longitudinal examinations of diffusion tensor imaging, hydrogen proton magnetic resonance spectroscopy imaging and neuropsychological assessment were performed after weeks 1 and 12 to elucidate the relationship between magnetic resonance imaging parameters and neurologic outcomes. By week 12, motor function had significantly improved, but cognitive function had deteriorated compared to week 1. Fractional anisotropy values for the ipsilateral cerebral peduncle correlated with motor function at week 1. No significant correlation between fractional anisotropy for the ipsilateral cerebral peduncle and the Fugl-Meyer Motor Scale was found at week 12. Fractional anisotropy values for the ipsilateral hippocampus were related to the Montreal Cognitive Assessment and Mini-Mental State Examination at weeks 1 and 12. Deep supratentorial hemorrhage may result in injury to distal regions, which correlate with impaired motor and cognitive function. Impact Journals 2020-03-08 /pmc/articles/PMC7093199/ /pubmed/32146443 http://dx.doi.org/10.18632/aging.102880 Text en Copyright © 2020 Song et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Song, Kangping
Liu, Xiaojie
Zheng, Qiuyue
Zhang, Lingling
Zhang, Hongying
Yu, Hailong
Zhu, Yan
Huang, Li-An
Chen, Yingzhu
Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome
title Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome
title_full Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome
title_fullStr Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome
title_full_unstemmed Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome
title_short Secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome
title_sort secondary injury to distal regions after intracerebral hemorrhage influence neurological functional outcome
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093199/
https://www.ncbi.nlm.nih.gov/pubmed/32146443
http://dx.doi.org/10.18632/aging.102880
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