Cargando…
Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps
Mitophagy, a conserved intracellular process by which mitochondria are eliminated via the autophagic machinery, is a quality control mechanism which facilitates maintenance of a functional mitochondrial network and cell homeostasis, making it a key process in development and longevity. Mitophagy has...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093328/ https://www.ncbi.nlm.nih.gov/pubmed/32258042 http://dx.doi.org/10.3389/fcell.2020.00171 |
_version_ | 1783510259671760896 |
---|---|
author | Zachari, Maria Ktistakis, Nicholas T. |
author_facet | Zachari, Maria Ktistakis, Nicholas T. |
author_sort | Zachari, Maria |
collection | PubMed |
description | Mitophagy, a conserved intracellular process by which mitochondria are eliminated via the autophagic machinery, is a quality control mechanism which facilitates maintenance of a functional mitochondrial network and cell homeostasis, making it a key process in development and longevity. Mitophagy has been linked to multiple human disorders, especially neurodegenerative diseases where the long-lived neurons are relying on clearance of old/damaged mitochondria to survive. During the past decade, the availability of novel tools to study mitophagy both in vitro and in vivo has significantly advanced our understanding of the molecular mechanisms governing this fundamental process in normal physiology and in various disease models. We here give an overview of the known mitophagy pathways and how they are induced, with a particular emphasis on the early events governing mitophagosome formation. |
format | Online Article Text |
id | pubmed-7093328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70933282020-04-01 Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps Zachari, Maria Ktistakis, Nicholas T. Front Cell Dev Biol Cell and Developmental Biology Mitophagy, a conserved intracellular process by which mitochondria are eliminated via the autophagic machinery, is a quality control mechanism which facilitates maintenance of a functional mitochondrial network and cell homeostasis, making it a key process in development and longevity. Mitophagy has been linked to multiple human disorders, especially neurodegenerative diseases where the long-lived neurons are relying on clearance of old/damaged mitochondria to survive. During the past decade, the availability of novel tools to study mitophagy both in vitro and in vivo has significantly advanced our understanding of the molecular mechanisms governing this fundamental process in normal physiology and in various disease models. We here give an overview of the known mitophagy pathways and how they are induced, with a particular emphasis on the early events governing mitophagosome formation. Frontiers Media S.A. 2020-03-18 /pmc/articles/PMC7093328/ /pubmed/32258042 http://dx.doi.org/10.3389/fcell.2020.00171 Text en Copyright © 2020 Zachari and Ktistakis. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zachari, Maria Ktistakis, Nicholas T. Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps |
title | Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps |
title_full | Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps |
title_fullStr | Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps |
title_full_unstemmed | Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps |
title_short | Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps |
title_sort | mammalian mitophagosome formation: a focus on the early signals and steps |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093328/ https://www.ncbi.nlm.nih.gov/pubmed/32258042 http://dx.doi.org/10.3389/fcell.2020.00171 |
work_keys_str_mv | AT zacharimaria mammalianmitophagosomeformationafocusontheearlysignalsandsteps AT ktistakisnicholast mammalianmitophagosomeformationafocusontheearlysignalsandsteps |