Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

Neurons maintain axonal homeostasis via employing a unique organization of the microtubule (MT) cytoskeleton, which supports axonal morphology and provides tracks for intracellular transport. Abnormal MT-based trafficking hallmarks the pathology of neurodegenerative diseases, but the exact mechanism...

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Detalles Bibliográficos
Autores principales: Negrete-Hurtado, A., Overhoff, M., Bera, S., De Bruyckere, E., Schätzmüller, K., Kye, M. J., Qin, C., Lammers, M., Kondylis, V., Neundorf, I., Kononenko, N. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093409/
https://www.ncbi.nlm.nih.gov/pubmed/32210230
http://dx.doi.org/10.1038/s41467-020-15287-9

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