Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion

Phenotypic heterogeneity exists within collectively invading packs of tumor cells, suggesting that cellular subtypes cooperate to drive invasion and metastasis. Here, we take a chemical biology approach to probe cell:cell cooperation within the collective invasion pack. These data reveal metabolic h...

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Detalles Bibliográficos
Autores principales: Commander, R., Wei, C., Sharma, A., Mouw, J. K., Burton, L. J., Summerbell, E., Mahboubi, D., Peterson, R. J., Konen, J., Zhou, W., Du, Y., Fu, H., Shanmugam, M., Marcus, A. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093428/
https://www.ncbi.nlm.nih.gov/pubmed/32210228
http://dx.doi.org/10.1038/s41467-020-15219-7

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