Insights from Microbial Transition State Theory on Monod’s Affinity Constant

Microbial transition state theory (MTS) offers a theoretically explicit mathematical model for substrate limited microbial growth. By considering a first order approximation of the MTS equation one recovers the well-known Monod’s expression for growth, which was regarded as a purely empirical functi...

Descripción completa

Detalles Bibliográficos
Autores principales: Ugalde-Salas, Pablo, Desmond-Le Quéméner, Elie, Harmand, Jérôme, Rapaport, Alain, Bouchez, Théodore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093443/
https://www.ncbi.nlm.nih.gov/pubmed/32210303
http://dx.doi.org/10.1038/s41598-020-62213-6
_version_ 1783510284622626816
author Ugalde-Salas, Pablo
Desmond-Le Quéméner, Elie
Harmand, Jérôme
Rapaport, Alain
Bouchez, Théodore
author_facet Ugalde-Salas, Pablo
Desmond-Le Quéméner, Elie
Harmand, Jérôme
Rapaport, Alain
Bouchez, Théodore
author_sort Ugalde-Salas, Pablo
collection PubMed
description Microbial transition state theory (MTS) offers a theoretically explicit mathematical model for substrate limited microbial growth. By considering a first order approximation of the MTS equation one recovers the well-known Monod’s expression for growth, which was regarded as a purely empirical function. The harvest volume of a cell as defined in MTS theory can then be related to the affinity concept, giving a new physical interpretation to it, and a new way to determine its value. Consequences of such a relationship are discussed.
format Online
Article
Text
id pubmed-7093443
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70934432020-03-27 Insights from Microbial Transition State Theory on Monod’s Affinity Constant Ugalde-Salas, Pablo Desmond-Le Quéméner, Elie Harmand, Jérôme Rapaport, Alain Bouchez, Théodore Sci Rep Article Microbial transition state theory (MTS) offers a theoretically explicit mathematical model for substrate limited microbial growth. By considering a first order approximation of the MTS equation one recovers the well-known Monod’s expression for growth, which was regarded as a purely empirical function. The harvest volume of a cell as defined in MTS theory can then be related to the affinity concept, giving a new physical interpretation to it, and a new way to determine its value. Consequences of such a relationship are discussed. Nature Publishing Group UK 2020-03-24 /pmc/articles/PMC7093443/ /pubmed/32210303 http://dx.doi.org/10.1038/s41598-020-62213-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ugalde-Salas, Pablo
Desmond-Le Quéméner, Elie
Harmand, Jérôme
Rapaport, Alain
Bouchez, Théodore
Insights from Microbial Transition State Theory on Monod’s Affinity Constant
title Insights from Microbial Transition State Theory on Monod’s Affinity Constant
title_full Insights from Microbial Transition State Theory on Monod’s Affinity Constant
title_fullStr Insights from Microbial Transition State Theory on Monod’s Affinity Constant
title_full_unstemmed Insights from Microbial Transition State Theory on Monod’s Affinity Constant
title_short Insights from Microbial Transition State Theory on Monod’s Affinity Constant
title_sort insights from microbial transition state theory on monod’s affinity constant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093443/
https://www.ncbi.nlm.nih.gov/pubmed/32210303
http://dx.doi.org/10.1038/s41598-020-62213-6
work_keys_str_mv AT ugaldesalaspablo insightsfrommicrobialtransitionstatetheoryonmonodsaffinityconstant
AT desmondlequemenerelie insightsfrommicrobialtransitionstatetheoryonmonodsaffinityconstant
AT harmandjerome insightsfrommicrobialtransitionstatetheoryonmonodsaffinityconstant
AT rapaportalain insightsfrommicrobialtransitionstatetheoryonmonodsaffinityconstant
AT boucheztheodore insightsfrommicrobialtransitionstatetheoryonmonodsaffinityconstant

Ejemplares similares