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A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves

Polymeric heart valves seem to be an attractive alternative to mechanical and biological prostheses as they are more durable, due to the superior properties of novel polymers, and have the biocompatibility and hemodynamics comparable to tissue substitutes. This study reports a comprehensive assessme...

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Autores principales: Ovcharenko, Evgeny A., Seifalian, Amelia, Rezvova, Maria A., Klyshnikov, Kirill Yu., Glushkova, Tatiana V., Akenteva, Tatyana N., Antonova, Larisa V., Velikanova, Elena A., Chernonosova, Vera S., Shevelev, Georgy Yu., Shishkova, Darya K., Krivkina, Evgeniya O., Kudryavceva, Yuliya A., Seifalian, Alexander M., Barbarash, Leonid S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093488/
https://www.ncbi.nlm.nih.gov/pubmed/32210287
http://dx.doi.org/10.1038/s41598-020-62122-8
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author Ovcharenko, Evgeny A.
Seifalian, Amelia
Rezvova, Maria A.
Klyshnikov, Kirill Yu.
Glushkova, Tatiana V.
Akenteva, Tatyana N.
Antonova, Larisa V.
Velikanova, Elena A.
Chernonosova, Vera S.
Shevelev, Georgy Yu.
Shishkova, Darya K.
Krivkina, Evgeniya O.
Kudryavceva, Yuliya A.
Seifalian, Alexander M.
Barbarash, Leonid S.
author_facet Ovcharenko, Evgeny A.
Seifalian, Amelia
Rezvova, Maria A.
Klyshnikov, Kirill Yu.
Glushkova, Tatiana V.
Akenteva, Tatyana N.
Antonova, Larisa V.
Velikanova, Elena A.
Chernonosova, Vera S.
Shevelev, Georgy Yu.
Shishkova, Darya K.
Krivkina, Evgeniya O.
Kudryavceva, Yuliya A.
Seifalian, Alexander M.
Barbarash, Leonid S.
author_sort Ovcharenko, Evgeny A.
collection PubMed
description Polymeric heart valves seem to be an attractive alternative to mechanical and biological prostheses as they are more durable, due to the superior properties of novel polymers, and have the biocompatibility and hemodynamics comparable to tissue substitutes. This study reports a comprehensive assessment of a nanocomposite based on the functionalised graphene oxide and poly(carbonate-urea)urethane with the trade name “Hastalex” in comparison with GORE-TEX, a commercial polymer routinely used for cardiovascular medical devices. Experimental data have proved that GORE-TEX has a 2.5-fold (longitudinal direction) and 3.5-fold (transverse direction) lower ultimate tensile strength in comparison with Hastalex (p < 0.05). The contact angles of Hastalex surfaces (85.2 ± 1.1°) significantly (p < 0.05) are lower than those of GORE-TEX (127.1 ± 6.8°). The highest number of viable cells Ea.hy 926 is on the Hastalex surface exceeding 7.5-fold when compared with the GORE-TEX surface (p < 0.001). The platelet deformation index for GORE-TEX is 2-fold higher than that of Hastalex polymer (p < 0.05). Calcium content is greater for GORE-TEX (8.4 mg/g) in comparison with Hastalex (0.55 mg/g). The results of this study have proven that Hastalex meets the main standards required for manufacturing artificial heart valves and has superior mechanical, hemocompatibility and calcific resistance properties in comparison with GORE-TEX.
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spelling pubmed-70934882020-03-27 A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves Ovcharenko, Evgeny A. Seifalian, Amelia Rezvova, Maria A. Klyshnikov, Kirill Yu. Glushkova, Tatiana V. Akenteva, Tatyana N. Antonova, Larisa V. Velikanova, Elena A. Chernonosova, Vera S. Shevelev, Georgy Yu. Shishkova, Darya K. Krivkina, Evgeniya O. Kudryavceva, Yuliya A. Seifalian, Alexander M. Barbarash, Leonid S. Sci Rep Article Polymeric heart valves seem to be an attractive alternative to mechanical and biological prostheses as they are more durable, due to the superior properties of novel polymers, and have the biocompatibility and hemodynamics comparable to tissue substitutes. This study reports a comprehensive assessment of a nanocomposite based on the functionalised graphene oxide and poly(carbonate-urea)urethane with the trade name “Hastalex” in comparison with GORE-TEX, a commercial polymer routinely used for cardiovascular medical devices. Experimental data have proved that GORE-TEX has a 2.5-fold (longitudinal direction) and 3.5-fold (transverse direction) lower ultimate tensile strength in comparison with Hastalex (p < 0.05). The contact angles of Hastalex surfaces (85.2 ± 1.1°) significantly (p < 0.05) are lower than those of GORE-TEX (127.1 ± 6.8°). The highest number of viable cells Ea.hy 926 is on the Hastalex surface exceeding 7.5-fold when compared with the GORE-TEX surface (p < 0.001). The platelet deformation index for GORE-TEX is 2-fold higher than that of Hastalex polymer (p < 0.05). Calcium content is greater for GORE-TEX (8.4 mg/g) in comparison with Hastalex (0.55 mg/g). The results of this study have proven that Hastalex meets the main standards required for manufacturing artificial heart valves and has superior mechanical, hemocompatibility and calcific resistance properties in comparison with GORE-TEX. Nature Publishing Group UK 2020-03-24 /pmc/articles/PMC7093488/ /pubmed/32210287 http://dx.doi.org/10.1038/s41598-020-62122-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Ovcharenko, Evgeny A.
Seifalian, Amelia
Rezvova, Maria A.
Klyshnikov, Kirill Yu.
Glushkova, Tatiana V.
Akenteva, Tatyana N.
Antonova, Larisa V.
Velikanova, Elena A.
Chernonosova, Vera S.
Shevelev, Georgy Yu.
Shishkova, Darya K.
Krivkina, Evgeniya O.
Kudryavceva, Yuliya A.
Seifalian, Alexander M.
Barbarash, Leonid S.
A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves
title A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves
title_full A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves
title_fullStr A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves
title_full_unstemmed A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves
title_short A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves
title_sort new nanocomposite copolymer based on functionalised graphene oxide for development of heart valves
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093488/
https://www.ncbi.nlm.nih.gov/pubmed/32210287
http://dx.doi.org/10.1038/s41598-020-62122-8
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