Cargando…
A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves
Polymeric heart valves seem to be an attractive alternative to mechanical and biological prostheses as they are more durable, due to the superior properties of novel polymers, and have the biocompatibility and hemodynamics comparable to tissue substitutes. This study reports a comprehensive assessme...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093488/ https://www.ncbi.nlm.nih.gov/pubmed/32210287 http://dx.doi.org/10.1038/s41598-020-62122-8 |
_version_ | 1783510293560688640 |
---|---|
author | Ovcharenko, Evgeny A. Seifalian, Amelia Rezvova, Maria A. Klyshnikov, Kirill Yu. Glushkova, Tatiana V. Akenteva, Tatyana N. Antonova, Larisa V. Velikanova, Elena A. Chernonosova, Vera S. Shevelev, Georgy Yu. Shishkova, Darya K. Krivkina, Evgeniya O. Kudryavceva, Yuliya A. Seifalian, Alexander M. Barbarash, Leonid S. |
author_facet | Ovcharenko, Evgeny A. Seifalian, Amelia Rezvova, Maria A. Klyshnikov, Kirill Yu. Glushkova, Tatiana V. Akenteva, Tatyana N. Antonova, Larisa V. Velikanova, Elena A. Chernonosova, Vera S. Shevelev, Georgy Yu. Shishkova, Darya K. Krivkina, Evgeniya O. Kudryavceva, Yuliya A. Seifalian, Alexander M. Barbarash, Leonid S. |
author_sort | Ovcharenko, Evgeny A. |
collection | PubMed |
description | Polymeric heart valves seem to be an attractive alternative to mechanical and biological prostheses as they are more durable, due to the superior properties of novel polymers, and have the biocompatibility and hemodynamics comparable to tissue substitutes. This study reports a comprehensive assessment of a nanocomposite based on the functionalised graphene oxide and poly(carbonate-urea)urethane with the trade name “Hastalex” in comparison with GORE-TEX, a commercial polymer routinely used for cardiovascular medical devices. Experimental data have proved that GORE-TEX has a 2.5-fold (longitudinal direction) and 3.5-fold (transverse direction) lower ultimate tensile strength in comparison with Hastalex (p < 0.05). The contact angles of Hastalex surfaces (85.2 ± 1.1°) significantly (p < 0.05) are lower than those of GORE-TEX (127.1 ± 6.8°). The highest number of viable cells Ea.hy 926 is on the Hastalex surface exceeding 7.5-fold when compared with the GORE-TEX surface (p < 0.001). The platelet deformation index for GORE-TEX is 2-fold higher than that of Hastalex polymer (p < 0.05). Calcium content is greater for GORE-TEX (8.4 mg/g) in comparison with Hastalex (0.55 mg/g). The results of this study have proven that Hastalex meets the main standards required for manufacturing artificial heart valves and has superior mechanical, hemocompatibility and calcific resistance properties in comparison with GORE-TEX. |
format | Online Article Text |
id | pubmed-7093488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70934882020-03-27 A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves Ovcharenko, Evgeny A. Seifalian, Amelia Rezvova, Maria A. Klyshnikov, Kirill Yu. Glushkova, Tatiana V. Akenteva, Tatyana N. Antonova, Larisa V. Velikanova, Elena A. Chernonosova, Vera S. Shevelev, Georgy Yu. Shishkova, Darya K. Krivkina, Evgeniya O. Kudryavceva, Yuliya A. Seifalian, Alexander M. Barbarash, Leonid S. Sci Rep Article Polymeric heart valves seem to be an attractive alternative to mechanical and biological prostheses as they are more durable, due to the superior properties of novel polymers, and have the biocompatibility and hemodynamics comparable to tissue substitutes. This study reports a comprehensive assessment of a nanocomposite based on the functionalised graphene oxide and poly(carbonate-urea)urethane with the trade name “Hastalex” in comparison with GORE-TEX, a commercial polymer routinely used for cardiovascular medical devices. Experimental data have proved that GORE-TEX has a 2.5-fold (longitudinal direction) and 3.5-fold (transverse direction) lower ultimate tensile strength in comparison with Hastalex (p < 0.05). The contact angles of Hastalex surfaces (85.2 ± 1.1°) significantly (p < 0.05) are lower than those of GORE-TEX (127.1 ± 6.8°). The highest number of viable cells Ea.hy 926 is on the Hastalex surface exceeding 7.5-fold when compared with the GORE-TEX surface (p < 0.001). The platelet deformation index for GORE-TEX is 2-fold higher than that of Hastalex polymer (p < 0.05). Calcium content is greater for GORE-TEX (8.4 mg/g) in comparison with Hastalex (0.55 mg/g). The results of this study have proven that Hastalex meets the main standards required for manufacturing artificial heart valves and has superior mechanical, hemocompatibility and calcific resistance properties in comparison with GORE-TEX. Nature Publishing Group UK 2020-03-24 /pmc/articles/PMC7093488/ /pubmed/32210287 http://dx.doi.org/10.1038/s41598-020-62122-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Ovcharenko, Evgeny A. Seifalian, Amelia Rezvova, Maria A. Klyshnikov, Kirill Yu. Glushkova, Tatiana V. Akenteva, Tatyana N. Antonova, Larisa V. Velikanova, Elena A. Chernonosova, Vera S. Shevelev, Georgy Yu. Shishkova, Darya K. Krivkina, Evgeniya O. Kudryavceva, Yuliya A. Seifalian, Alexander M. Barbarash, Leonid S. A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves |
title | A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves |
title_full | A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves |
title_fullStr | A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves |
title_full_unstemmed | A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves |
title_short | A New Nanocomposite Copolymer Based On Functionalised Graphene Oxide for Development of Heart Valves |
title_sort | new nanocomposite copolymer based on functionalised graphene oxide for development of heart valves |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093488/ https://www.ncbi.nlm.nih.gov/pubmed/32210287 http://dx.doi.org/10.1038/s41598-020-62122-8 |
work_keys_str_mv | AT ovcharenkoevgenya anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT seifalianamelia anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT rezvovamariaa anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT klyshnikovkirillyu anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT glushkovatatianav anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT akentevatatyanan anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT antonovalarisav anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT velikanovaelenaa anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT chernonosovaveras anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT shevelevgeorgyyu anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT shishkovadaryak anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT krivkinaevgeniyao anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT kudryavcevayuliyaa anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT seifalianalexanderm anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT barbarashleonids anewnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT ovcharenkoevgenya newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT seifalianamelia newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT rezvovamariaa newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT klyshnikovkirillyu newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT glushkovatatianav newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT akentevatatyanan newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT antonovalarisav newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT velikanovaelenaa newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT chernonosovaveras newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT shevelevgeorgyyu newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT shishkovadaryak newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT krivkinaevgeniyao newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT kudryavcevayuliyaa newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT seifalianalexanderm newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves AT barbarashleonids newnanocompositecopolymerbasedonfunctionalisedgrapheneoxidefordevelopmentofheartvalves |