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Haemorrhagic transformation following ischaemic stroke: A retrospective study
The aim of this study was to identify the prevalence of haemorrhagic transformation (HT) in patients with ischaemic stroke, and evaluate its association with medical comorbidities, stroke subtypes, premorbid medication, and long-term survival. To achieve this, we performed a retrospective analysis o...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093519/ https://www.ncbi.nlm.nih.gov/pubmed/32210323 http://dx.doi.org/10.1038/s41598-020-62230-5 |
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author | Pande, S. D. Win, M. M. Khine, A. A. Zaw, E. M. Manoharraj, N. Lolong, L. Tin, A. S. |
author_facet | Pande, S. D. Win, M. M. Khine, A. A. Zaw, E. M. Manoharraj, N. Lolong, L. Tin, A. S. |
author_sort | Pande, S. D. |
collection | PubMed |
description | The aim of this study was to identify the prevalence of haemorrhagic transformation (HT) in patients with ischaemic stroke, and evaluate its association with medical comorbidities, stroke subtypes, premorbid medication, and long-term survival. To achieve this, we performed a retrospective analysis of 527 consecutive stroke rehabilitation patients. Of these, 102 (19.4%) developed HT. Older patients, and those with large artery strokes, had a higher risk of HT. Forty-one patients received alteplase (rtPA), of which 15 (36.6%) developed HT. A total of 129 (24.5%) patients were taking aspirin prior to their stroke and, of these, 39 (30.2%) developed HT. Twenty-three (4.36%) patients were taking vitamin k antagonists, prior to stroke, of which 14 (60.9%) developed HT. There were 102 patients (19.35%) with underlying atrial fibrillation, of whom 55 (53.9%) developed HT. Patients with known ischaemic heart disease had an increased risk of HT, and patients with HT had significantly lower total cholesterol levels (4.96 vs. 5.34) and lower LDL cholesterol levels (3.20 vs. 3.5). In conclusion, older age, atrial fibrillation, treatment with oral anticoagulants and antiplatelet medications prior to stroke, low total and LDL cholesterol, and rtPA use, are all associated with HT. Survival was not affected by the presence of HT. |
format | Online Article Text |
id | pubmed-7093519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-70935192020-03-27 Haemorrhagic transformation following ischaemic stroke: A retrospective study Pande, S. D. Win, M. M. Khine, A. A. Zaw, E. M. Manoharraj, N. Lolong, L. Tin, A. S. Sci Rep Article The aim of this study was to identify the prevalence of haemorrhagic transformation (HT) in patients with ischaemic stroke, and evaluate its association with medical comorbidities, stroke subtypes, premorbid medication, and long-term survival. To achieve this, we performed a retrospective analysis of 527 consecutive stroke rehabilitation patients. Of these, 102 (19.4%) developed HT. Older patients, and those with large artery strokes, had a higher risk of HT. Forty-one patients received alteplase (rtPA), of which 15 (36.6%) developed HT. A total of 129 (24.5%) patients were taking aspirin prior to their stroke and, of these, 39 (30.2%) developed HT. Twenty-three (4.36%) patients were taking vitamin k antagonists, prior to stroke, of which 14 (60.9%) developed HT. There were 102 patients (19.35%) with underlying atrial fibrillation, of whom 55 (53.9%) developed HT. Patients with known ischaemic heart disease had an increased risk of HT, and patients with HT had significantly lower total cholesterol levels (4.96 vs. 5.34) and lower LDL cholesterol levels (3.20 vs. 3.5). In conclusion, older age, atrial fibrillation, treatment with oral anticoagulants and antiplatelet medications prior to stroke, low total and LDL cholesterol, and rtPA use, are all associated with HT. Survival was not affected by the presence of HT. Nature Publishing Group UK 2020-03-24 /pmc/articles/PMC7093519/ /pubmed/32210323 http://dx.doi.org/10.1038/s41598-020-62230-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pande, S. D. Win, M. M. Khine, A. A. Zaw, E. M. Manoharraj, N. Lolong, L. Tin, A. S. Haemorrhagic transformation following ischaemic stroke: A retrospective study |
title | Haemorrhagic transformation following ischaemic stroke: A retrospective study |
title_full | Haemorrhagic transformation following ischaemic stroke: A retrospective study |
title_fullStr | Haemorrhagic transformation following ischaemic stroke: A retrospective study |
title_full_unstemmed | Haemorrhagic transformation following ischaemic stroke: A retrospective study |
title_short | Haemorrhagic transformation following ischaemic stroke: A retrospective study |
title_sort | haemorrhagic transformation following ischaemic stroke: a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093519/ https://www.ncbi.nlm.nih.gov/pubmed/32210323 http://dx.doi.org/10.1038/s41598-020-62230-5 |
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