Cargando…

CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant epoxygenase in the heart and has multifunctional properties including bioactivation of arachidonic acid to epoxyeicosatrienoic acids, which, in turn, have been implicated in mediating several cardiovascular conditions. U...

Descripción completa

Detalles Bibliográficos
Autores principales:	Evangelista, Eric A., Aliwarga, Theresa, Sotoodehnia, Nona, Jensen, Paul N., McKnight, Barbara, Lemaitre, Rozenn N., Totah, Rheem A., Gharib, Sina A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093536/ https://www.ncbi.nlm.nih.gov/pubmed/32210298 http://dx.doi.org/10.1038/s41598-020-62174-w

Ejemplares similares

Regulation of CYP2J2 and EET Levels in Cardiac Disease and Diabetes
por: Aliwarga, Theresa, et al.
Publicado: (2018)

Higher Epoxyeicosatrienoic Acids in Cardiomyocytes-Specific CYP2J2 Transgenic Mice Are Associated with Improved Myocardial Remodeling
por: Aliwarga, Theresa, et al.
Publicado: (2020)

Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation
por: Aliwarga, Theresa, et al.
Publicado: (2022)

Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
por: Evangelista, Eric A., et al.
Publicado: (2020)

Plasma epoxyeicosatrienoic acids and diabetes-related cardiovascular disease: The cardiovascular health study
por: Lemaitre, Rozenn N., et al.
Publicado: (2022)

Plasma epoxyeicosatrienoic acids and dihydroxyeicosatrieonic acids, insulin, glucose and risk of diabetes: The strong heart study
por: Lemaitre, Rozenn N., et al.
Publicado: (2021)

Plasma sphingolipids, lung function and COPD: the Cardiovascular Health Study
por: Gharib, Arya R., et al.
Publicado: (2023)

Plasma ceramides containing saturated fatty acids are associated with risk of type 2 diabetes
por: Fretts, Amanda M., et al.
Publicado: (2021)

Admission respiratory status predicts mortality in COVID‐19
por: Chatterjee, Neal A., et al.
Publicado: (2021)

Circulating n-3 fatty acids and trans-fatty acids, PLA2G2A gene variation and sudden cardiac arrest
por: Lemaitre, Rozenn N., et al.
Publicado: (2016)

Association of Trimethylamine N-Oxide and Related Metabolites in Plasma and Incident Type 2 Diabetes: The Cardiovascular Health Study
por: Lemaitre, Rozenn N., et al.
Publicado: (2021)

Circulating ceramides and sphingomyelins and the risk of incident cardiovascular disease among people with diabetes: the strong heart study
por: Jensen, Paul N., et al.
Publicado: (2022)

Plasma Ceramides and Sphingomyelins and Sudden Cardiac Death in the Cardiovascular Health Study
por: Bockus, Lee B., et al.
Publicado: (2023)

Circulating sphingolipids, fasting glucose, and impaired fasting glucose: The Strong Heart Family Study
por: Jensen, Paul N., et al.
Publicado: (2018)

Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study
por: Jensen, Paul N., et al.
Publicado: (2020)

Circulating Very Long‐Chain Saturated Fatty Acids and Heart Failure: The Cardiovascular Health Study
por: Lemaitre, Rozenn N., et al.
Publicado: (2018)

Associations of Plasma Phospholipid SFAs with Total and Cause-Specific Mortality in Older Adults Differ According to SFA Chain Length(1)(2)(3)(4)
por: Fretts, Amanda M, et al.
Publicado: (2016)

Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study
por: Lemaitre, Rozenn N., et al.
Publicado: (2018)

Plasma Phospholipid Saturated Fatty Acids and Incident Atrial Fibrillation: The Cardiovascular Health Study
por: Fretts, Amanda M., et al.
Publicado: (2014)

Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril
por: Maldonato, Benjamin J., et al.
Publicado: (2021)

The development of novel cytochrome P450 2J2 (CYP2J2) inhibitor and the underlying interaction between inhibitor and CYP2J2
por: Tian, Xiangge, et al.
Publicado: (2021)

Longitudinal Plasma Measures of Trimethylamine N‐Oxide and Risk of Atherosclerotic Cardiovascular Disease Events in Community‐Based Older Adults
por: Lee, Yujin, et al.
Publicado: (2021)

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice
por: Hanif, Ahmad, et al.
Publicado: (2017)

Role of Cyp2j6 in Brown Adipogenesis
por: Zhao, Ling, et al.
Publicado: (2022)

Reductions in Hydrogen Sulfide and Changes in Mitochondrial Quality Control Proteins Are Evident in the Early Phases of the Corneally Kindled Mouse Model of Epilepsy
por: Cho, Christi, et al.
Publicado: (2022)

CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy
por: Westphal, Christina, et al.
Publicado: (2013)

In vitro and In silico studies of interactions of cathinone with human recombinant cytochrome P450 CYP(1A2), CYP2A6, CYP2B6, CYP2C8, CYP2C19, CYP2E1, CYP2J2, and CYP3A5
por: Lim, Sharoen Yu Ming, et al.
Publicado: (2022)

Inducible CYP2J2 and Its Product 11,12-EET Promotes Bacterial Phagocytosis: A Role for CYP2J2 Deficiency in the Pathogenesis of Crohn’s Disease?
por: Bystrom, Jonas, et al.
Publicado: (2013)

Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults
por: Djoussé, Luc, et al.
Publicado: (2013)

Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation
por: Zhang, Donghong, et al.
Publicado: (2016)

The Protective Role of Brain CYP2J in Parkinson's Disease Models
por: Li, Yueran, et al.
Publicado: (2018)

The Epoxygenases CYP2J2 Activates the Nuclear Receptor PPARα In Vitro and In Vivo
por: Wray, Jessica A., et al.
Publicado: (2009)

Plasma Trimethylamine‐N ‐Oxide and Incident Ischemic Stroke: The Cardiovascular Health Study and the Multi‐Ethnic Study of Atherosclerosis
por: Lemaitre, Rozenn N., et al.
Publicado: (2023)

Deletion of the Murine Cytochrome P450 Cyp2j Locus by Fused BAC-Mediated Recombination Identifies a Role for Cyp2j in the Pulmonary Vascular Response to Hypoxia
por: Zhou, Guo Ling, et al.
Publicado: (2013)

Cyp2j5-Gene Deletion Affects on Acetylcholine and Adenosine-Induced Relaxation in Mice: Role of Angiotensin-II and CYP-Epoxygenase Inhibitor
por: Agba, Stephanie, et al.
Publicado: (2020)

Endothelium‐specific CYP2J2 overexpression attenuates age‐related insulin resistance
por: Yang, Yan, et al.
Publicado: (2018)

Genetic polymorphisms of the drug-metabolizing enzyme CYP2J2 in a Tibetan population
por: Cao, Peilong, et al.
Publicado: (2018)

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice
por: Kapelyukh, Y., et al.
Publicado: (2019)

Allelic variants between mouse substrains BALB/cJ and BALB/cByJ influence mononuclear cardiomyocyte composition and cardiomyocyte nuclear ploidy
por: Gan, Peiheng, et al.
Publicado: (2020)

Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults
por: Fretts, Amanda M., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_m35du2mnt30opprslmnupnthe5