Cargando…

The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example

The literature contains an extensive panel of studies focusing on the costs of animal diseases. The losses of an agriculture holding can be influenced by many factors since farming is a complex system and diseases are closely interrelated. Meta-analysis can be used to detect effects (i.e., change in...

Descripción completa

Detalles Bibliográficos
Autores principales: Raboisson, Didier, Ferchiou, Ahmed, Pinior, Beate, Gautier, Thomas, Sans, Pierre, Lhermie, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093557/
https://www.ncbi.nlm.nih.gov/pubmed/32258070
http://dx.doi.org/10.3389/fvets.2020.00149
_version_ 1783510308074029056
author Raboisson, Didier
Ferchiou, Ahmed
Pinior, Beate
Gautier, Thomas
Sans, Pierre
Lhermie, Guillaume
author_facet Raboisson, Didier
Ferchiou, Ahmed
Pinior, Beate
Gautier, Thomas
Sans, Pierre
Lhermie, Guillaume
author_sort Raboisson, Didier
collection PubMed
description The literature contains an extensive panel of studies focusing on the costs of animal diseases. The losses of an agriculture holding can be influenced by many factors since farming is a complex system and diseases are closely interrelated. Meta-analysis can be used to detect effects (i.e., change in clinical mastitis losses here) across studies and to identify factors that may influence those effects. This includes the external validity of the published study results with regard to the input parameters and the internal validity of the study, particularly how other diseases related to the target disease were accounted for. Mixed-effect meta-regressions were performed to estimate the mean clinical mastitis losses per case across the literature and to elucidate to what extent clinical mastitis losses are influenced by (i) general factors, such as etiology; (ii) the types of losses that contribute to the total mastitis losses; and (iii) prices. In total, 82 observations from nine studies were included in the meta-analysis to assess mean clinical mastitis losses per case. The multivariate meta-regression showed that etiology significantly influenced the clinical mastitis loss per case. The mean loss was determined to be €224 per case for all published etiologies. In detail, mean losses equalled €457 and €101 per case of clinical mastitis due to gram-negative and gram-positive bacteria, respectively, and €428 and €74 per case of clinical mastitis due to Escherichia coli and Staphylococcus aureus, respectively. Additionally, the mean loss obtained depended on whether diagnostic costs and reduced feed intake in cases of mastitis were included in the clinical mastitis loss calculation. The monetary values of labor cost, drug cost and culling cost, as well as treatment price (all included), significantly influenced the clinical mastitis losses per case. All other tested moderators were not associated with mastitis losses, highlighting the need for more standardized economic studies, for both methods and ways results are presented, and suggesting that the mastitis losses assessed in the literature cannot be extrapolated (limited external validity). Although meta-analyses are useful to overview the burden of diseases across studies, their ability to summarize extensive literature with various economic assessments is limited. These limitations in loss assessments also suggest the need to focus on management strategies rather than on pure monetary estimations of disease costs, at least for production diseases at the farm level.
format Online
Article
Text
id pubmed-7093557
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-70935572020-04-01 The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example Raboisson, Didier Ferchiou, Ahmed Pinior, Beate Gautier, Thomas Sans, Pierre Lhermie, Guillaume Front Vet Sci Veterinary Science The literature contains an extensive panel of studies focusing on the costs of animal diseases. The losses of an agriculture holding can be influenced by many factors since farming is a complex system and diseases are closely interrelated. Meta-analysis can be used to detect effects (i.e., change in clinical mastitis losses here) across studies and to identify factors that may influence those effects. This includes the external validity of the published study results with regard to the input parameters and the internal validity of the study, particularly how other diseases related to the target disease were accounted for. Mixed-effect meta-regressions were performed to estimate the mean clinical mastitis losses per case across the literature and to elucidate to what extent clinical mastitis losses are influenced by (i) general factors, such as etiology; (ii) the types of losses that contribute to the total mastitis losses; and (iii) prices. In total, 82 observations from nine studies were included in the meta-analysis to assess mean clinical mastitis losses per case. The multivariate meta-regression showed that etiology significantly influenced the clinical mastitis loss per case. The mean loss was determined to be €224 per case for all published etiologies. In detail, mean losses equalled €457 and €101 per case of clinical mastitis due to gram-negative and gram-positive bacteria, respectively, and €428 and €74 per case of clinical mastitis due to Escherichia coli and Staphylococcus aureus, respectively. Additionally, the mean loss obtained depended on whether diagnostic costs and reduced feed intake in cases of mastitis were included in the clinical mastitis loss calculation. The monetary values of labor cost, drug cost and culling cost, as well as treatment price (all included), significantly influenced the clinical mastitis losses per case. All other tested moderators were not associated with mastitis losses, highlighting the need for more standardized economic studies, for both methods and ways results are presented, and suggesting that the mastitis losses assessed in the literature cannot be extrapolated (limited external validity). Although meta-analyses are useful to overview the burden of diseases across studies, their ability to summarize extensive literature with various economic assessments is limited. These limitations in loss assessments also suggest the need to focus on management strategies rather than on pure monetary estimations of disease costs, at least for production diseases at the farm level. Frontiers Media S.A. 2020-03-18 /pmc/articles/PMC7093557/ /pubmed/32258070 http://dx.doi.org/10.3389/fvets.2020.00149 Text en Copyright © 2020 Raboisson, Ferchiou, Pinior, Gautier, Sans and Lhermie. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Raboisson, Didier
Ferchiou, Ahmed
Pinior, Beate
Gautier, Thomas
Sans, Pierre
Lhermie, Guillaume
The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example
title The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example
title_full The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example
title_fullStr The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example
title_full_unstemmed The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example
title_short The Use of Meta-Analysis for the Measurement of Animal Disease Burden: Losses Due to Clinical Mastitis as an Example
title_sort use of meta-analysis for the measurement of animal disease burden: losses due to clinical mastitis as an example
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093557/
https://www.ncbi.nlm.nih.gov/pubmed/32258070
http://dx.doi.org/10.3389/fvets.2020.00149
work_keys_str_mv AT raboissondidier theuseofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT ferchiouahmed theuseofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT piniorbeate theuseofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT gautierthomas theuseofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT sanspierre theuseofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT lhermieguillaume theuseofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT raboissondidier useofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT ferchiouahmed useofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT piniorbeate useofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT gautierthomas useofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT sanspierre useofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample
AT lhermieguillaume useofmetaanalysisforthemeasurementofanimaldiseaseburdenlossesduetoclinicalmastitisasanexample