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Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer

The potential values of Chinese herbal formulas in treating various diseases are well known. In addition to more than 2,000 years of history, herbal medicine is appreciated for its remarkable efficacy in a lot of cases, which warrants a role in public health care worldwide, especially in East Asian...

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Autores principales: Chen, Feiyu, Zhong, Zhangfeng, Tan, Hor Yue, Guo, Wei, Zhang, Cheng, Tan, Chi-wing, Li, Sha, Wang, Ning, Feng, Yibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093640/
https://www.ncbi.nlm.nih.gov/pubmed/32256363
http://dx.doi.org/10.3389/fphar.2020.00293
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author Chen, Feiyu
Zhong, Zhangfeng
Tan, Hor Yue
Guo, Wei
Zhang, Cheng
Tan, Chi-wing
Li, Sha
Wang, Ning
Feng, Yibin
author_facet Chen, Feiyu
Zhong, Zhangfeng
Tan, Hor Yue
Guo, Wei
Zhang, Cheng
Tan, Chi-wing
Li, Sha
Wang, Ning
Feng, Yibin
author_sort Chen, Feiyu
collection PubMed
description The potential values of Chinese herbal formulas in treating various diseases are well known. In addition to more than 2,000 years of history, herbal medicine is appreciated for its remarkable efficacy in a lot of cases, which warrants a role in public health care worldwide, especially in East Asian countries. Liver cancer is the second most fatal cancer across the world. Recent studies have extensively investigated the chemical profiles and pharmacological effects of Chinese herbal medicine formulas on liver cancer. Either through observational follow-up or experimental studies, multiple herbal formulas have benefits implicated in the management of liver cancer. However, complex composition of each formula imposes restrictions on promoting clinical practice and global recognition. Therefore, understanding the mode of action of Chinese herbal medicine formulas in depth may offer sufficient evidence for their clinical use. This review highlighted the chemical characteristics and molecular mechanisms of actions of prominent Chinese herbal medicine formulas and summarized the correlated findings on the potential use in liver cancer treatment. At last, the present progresses of Chinese herbal medicine formulas in the perspective of clinical trials are discussed.
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spelling pubmed-70936402020-04-01 Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer Chen, Feiyu Zhong, Zhangfeng Tan, Hor Yue Guo, Wei Zhang, Cheng Tan, Chi-wing Li, Sha Wang, Ning Feng, Yibin Front Pharmacol Pharmacology The potential values of Chinese herbal formulas in treating various diseases are well known. In addition to more than 2,000 years of history, herbal medicine is appreciated for its remarkable efficacy in a lot of cases, which warrants a role in public health care worldwide, especially in East Asian countries. Liver cancer is the second most fatal cancer across the world. Recent studies have extensively investigated the chemical profiles and pharmacological effects of Chinese herbal medicine formulas on liver cancer. Either through observational follow-up or experimental studies, multiple herbal formulas have benefits implicated in the management of liver cancer. However, complex composition of each formula imposes restrictions on promoting clinical practice and global recognition. Therefore, understanding the mode of action of Chinese herbal medicine formulas in depth may offer sufficient evidence for their clinical use. This review highlighted the chemical characteristics and molecular mechanisms of actions of prominent Chinese herbal medicine formulas and summarized the correlated findings on the potential use in liver cancer treatment. At last, the present progresses of Chinese herbal medicine formulas in the perspective of clinical trials are discussed. Frontiers Media S.A. 2020-03-18 /pmc/articles/PMC7093640/ /pubmed/32256363 http://dx.doi.org/10.3389/fphar.2020.00293 Text en Copyright © 2020 Chen, Zhong, Tan, Guo, Zhang, Tan, Li, Wang and Feng http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Feiyu
Zhong, Zhangfeng
Tan, Hor Yue
Guo, Wei
Zhang, Cheng
Tan, Chi-wing
Li, Sha
Wang, Ning
Feng, Yibin
Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer
title Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer
title_full Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer
title_fullStr Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer
title_full_unstemmed Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer
title_short Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas: Therapeutic Alternatives for Liver Cancer
title_sort uncovering the anticancer mechanisms of chinese herbal medicine formulas: therapeutic alternatives for liver cancer
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093640/
https://www.ncbi.nlm.nih.gov/pubmed/32256363
http://dx.doi.org/10.3389/fphar.2020.00293
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