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Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that encompasses esophageal symptoms along with eosinophilic infiltration of the esophageal epithelium. EoE is an evolving disease that has been a subject of interest to many researchers since the first studies recognized this conditio...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Academy of Family Medicine
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093678/ https://www.ncbi.nlm.nih.gov/pubmed/32062959 http://dx.doi.org/10.4082/kjfm.18.0162 |
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author | Mari, Amir Tsoukali, Emmanouela Yaccob, Afif |
author_facet | Mari, Amir Tsoukali, Emmanouela Yaccob, Afif |
author_sort | Mari, Amir |
collection | PubMed |
description | Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that encompasses esophageal symptoms along with eosinophilic infiltration of the esophageal epithelium. EoE is an evolving disease that has been a subject of interest to many researchers since the first studies recognized this condition as a new and distinct clinicopathological entity 25 years ago. Clinical presentation in adult patients may include dysphagia, food impaction, vomiting, and reflux symptoms. The diagnosis of EoE is based on the combination of clinical history suggestive of esophageal dysfunction, endoscopic features indicative of the disease, and histology revealing eosinophilic infiltration of the esophageal epithelium that persists after a trial of proton pump inhibitor therapy along with the exclusion of other disorders that may be associated with esophageal tissue eosinophilia. The interplay between EoE and gastroesophageal reflux disease (GERD) is complex, and differentiating these two conditions continues to be difficult and challenging in clinical practice. The mainstay treatment includes dietary modification, topical steroids, and/or endoscopic dilation. The primary care physician (PCP) plays an important role in improving patient care and quality of life by ensuring early referral and participating in management and follow-up. This article provides an overview of the current knowledge base regarding the disease including epidemiology, genetics, pathogenesis, common clinical presentations, the interplay between EoE and GERD, diagnostic approaches, and therapeutic options available to the PCP. |
format | Online Article Text |
id | pubmed-7093678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Academy of Family Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-70936782020-04-02 Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease Mari, Amir Tsoukali, Emmanouela Yaccob, Afif Korean J Fam Med Review Article Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that encompasses esophageal symptoms along with eosinophilic infiltration of the esophageal epithelium. EoE is an evolving disease that has been a subject of interest to many researchers since the first studies recognized this condition as a new and distinct clinicopathological entity 25 years ago. Clinical presentation in adult patients may include dysphagia, food impaction, vomiting, and reflux symptoms. The diagnosis of EoE is based on the combination of clinical history suggestive of esophageal dysfunction, endoscopic features indicative of the disease, and histology revealing eosinophilic infiltration of the esophageal epithelium that persists after a trial of proton pump inhibitor therapy along with the exclusion of other disorders that may be associated with esophageal tissue eosinophilia. The interplay between EoE and gastroesophageal reflux disease (GERD) is complex, and differentiating these two conditions continues to be difficult and challenging in clinical practice. The mainstay treatment includes dietary modification, topical steroids, and/or endoscopic dilation. The primary care physician (PCP) plays an important role in improving patient care and quality of life by ensuring early referral and participating in management and follow-up. This article provides an overview of the current knowledge base regarding the disease including epidemiology, genetics, pathogenesis, common clinical presentations, the interplay between EoE and GERD, diagnostic approaches, and therapeutic options available to the PCP. Korean Academy of Family Medicine 2020-03 2020-02-17 /pmc/articles/PMC7093678/ /pubmed/32062959 http://dx.doi.org/10.4082/kjfm.18.0162 Text en Copyright © 2020 The Korean Academy of Family Medicine This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Mari, Amir Tsoukali, Emmanouela Yaccob, Afif Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease |
title | Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease |
title_full | Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease |
title_fullStr | Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease |
title_full_unstemmed | Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease |
title_short | Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease |
title_sort | eosinophilic esophagitis in adults: a concise overview of an evolving disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093678/ https://www.ncbi.nlm.nih.gov/pubmed/32062959 http://dx.doi.org/10.4082/kjfm.18.0162 |
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