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Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease

Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that encompasses esophageal symptoms along with eosinophilic infiltration of the esophageal epithelium. EoE is an evolving disease that has been a subject of interest to many researchers since the first studies recognized this conditio...

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Autores principales: Mari, Amir, Tsoukali, Emmanouela, Yaccob, Afif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Academy of Family Medicine 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093678/
https://www.ncbi.nlm.nih.gov/pubmed/32062959
http://dx.doi.org/10.4082/kjfm.18.0162
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author Mari, Amir
Tsoukali, Emmanouela
Yaccob, Afif
author_facet Mari, Amir
Tsoukali, Emmanouela
Yaccob, Afif
author_sort Mari, Amir
collection PubMed
description Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that encompasses esophageal symptoms along with eosinophilic infiltration of the esophageal epithelium. EoE is an evolving disease that has been a subject of interest to many researchers since the first studies recognized this condition as a new and distinct clinicopathological entity 25 years ago. Clinical presentation in adult patients may include dysphagia, food impaction, vomiting, and reflux symptoms. The diagnosis of EoE is based on the combination of clinical history suggestive of esophageal dysfunction, endoscopic features indicative of the disease, and histology revealing eosinophilic infiltration of the esophageal epithelium that persists after a trial of proton pump inhibitor therapy along with the exclusion of other disorders that may be associated with esophageal tissue eosinophilia. The interplay between EoE and gastroesophageal reflux disease (GERD) is complex, and differentiating these two conditions continues to be difficult and challenging in clinical practice. The mainstay treatment includes dietary modification, topical steroids, and/or endoscopic dilation. The primary care physician (PCP) plays an important role in improving patient care and quality of life by ensuring early referral and participating in management and follow-up. This article provides an overview of the current knowledge base regarding the disease including epidemiology, genetics, pathogenesis, common clinical presentations, the interplay between EoE and GERD, diagnostic approaches, and therapeutic options available to the PCP.
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spelling pubmed-70936782020-04-02 Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease Mari, Amir Tsoukali, Emmanouela Yaccob, Afif Korean J Fam Med Review Article Eosinophilic esophagitis (EoE) is a chronic inflammatory disease that encompasses esophageal symptoms along with eosinophilic infiltration of the esophageal epithelium. EoE is an evolving disease that has been a subject of interest to many researchers since the first studies recognized this condition as a new and distinct clinicopathological entity 25 years ago. Clinical presentation in adult patients may include dysphagia, food impaction, vomiting, and reflux symptoms. The diagnosis of EoE is based on the combination of clinical history suggestive of esophageal dysfunction, endoscopic features indicative of the disease, and histology revealing eosinophilic infiltration of the esophageal epithelium that persists after a trial of proton pump inhibitor therapy along with the exclusion of other disorders that may be associated with esophageal tissue eosinophilia. The interplay between EoE and gastroesophageal reflux disease (GERD) is complex, and differentiating these two conditions continues to be difficult and challenging in clinical practice. The mainstay treatment includes dietary modification, topical steroids, and/or endoscopic dilation. The primary care physician (PCP) plays an important role in improving patient care and quality of life by ensuring early referral and participating in management and follow-up. This article provides an overview of the current knowledge base regarding the disease including epidemiology, genetics, pathogenesis, common clinical presentations, the interplay between EoE and GERD, diagnostic approaches, and therapeutic options available to the PCP. Korean Academy of Family Medicine 2020-03 2020-02-17 /pmc/articles/PMC7093678/ /pubmed/32062959 http://dx.doi.org/10.4082/kjfm.18.0162 Text en Copyright © 2020 The Korean Academy of Family Medicine This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mari, Amir
Tsoukali, Emmanouela
Yaccob, Afif
Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
title Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
title_full Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
title_fullStr Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
title_full_unstemmed Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
title_short Eosinophilic Esophagitis in Adults: A Concise Overview of an Evolving Disease
title_sort eosinophilic esophagitis in adults: a concise overview of an evolving disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093678/
https://www.ncbi.nlm.nih.gov/pubmed/32062959
http://dx.doi.org/10.4082/kjfm.18.0162
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