A young child with HIV and unsteady gait: A case report

BACKGROUND: We would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol. CASE PRESENTATION: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infec...

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Detalles Bibliográficos
Autores principales: Yazbeck, Nadine, Youssef, Yolla, Hanna-Wakim, Rima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093736/
https://www.ncbi.nlm.nih.gov/pubmed/32226753
http://dx.doi.org/10.1016/j.idcr.2019.e00643
Descripción
Sumario:BACKGROUND: We would like to raise awareness about the toxicities related to the added excipients present in the oral solution of Liponavir/ritonavir in particular alcohol and propylene glycol. CASE PRESENTATION: In this case report, we describe an 18 month-old child with a newly diagnosed HIV infection on antiretroviral therapy (ART). She developed shortly after starting the ART unsteady gait and imbalance. CONCLUSIONS: The excipient-excipient interaction in Lopinavir/ritonavir may contribute to major toxicities not only in premature neonates and infants; but also in older children specifically from Asian ethnicity.

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