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Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome
OBJECTIVE: Ribavirin and corticosteroids were used widely as front-line treatments for severe acute respiratory syndrome; however, previous evaluations were inconclusive. We assessed the effectiveness of ribavirin and corticosteroids as the initial treatment for severe acute respiratory syndrome usi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093860/ https://www.ncbi.nlm.nih.gov/pubmed/19958895 http://dx.doi.org/10.1016/j.amjmed.2009.07.018 |
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author | Lau, Eric H.Y. Cowling, Benjamin J. Muller, Matthew P. Ho, Lai-Ming Tsang, Thomas Lo, Su-Vui Louie, Marie Leung, Gabriel M. |
author_facet | Lau, Eric H.Y. Cowling, Benjamin J. Muller, Matthew P. Ho, Lai-Ming Tsang, Thomas Lo, Su-Vui Louie, Marie Leung, Gabriel M. |
author_sort | Lau, Eric H.Y. |
collection | PubMed |
description | OBJECTIVE: Ribavirin and corticosteroids were used widely as front-line treatments for severe acute respiratory syndrome; however, previous evaluations were inconclusive. We assessed the effectiveness of ribavirin and corticosteroids as the initial treatment for severe acute respiratory syndrome using propensity score analysis. METHODS: We analyzed data on 1755 patients in Hong Kong and 191 patients in Toronto with severe acute respiratory syndrome using a generalized propensity score approach. RESULTS: The adjusted excess case fatality ratios of patients with severe acute respiratory syndrome receiving the combined therapy of ribavirin and corticosteroids within 2 days of admission, compared with those receiving neither treatment within 2 days of admission, were 3.8% (95% confidence interval, −1.5 to 9.2) in Hong Kong and 2.1% (95% confidence interval, −44.3 to 48.5) in Toronto. CONCLUSIONS: Our results add strength to the hypothesis that the combination of ribavirin and corticosteroids has no therapeutic benefit when given early during severe acute respiratory syndrome infection. Further studies may investigate the effects of these treatments later in disease course. |
format | Online Article Text |
id | pubmed-7093860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70938602020-03-25 Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome Lau, Eric H.Y. Cowling, Benjamin J. Muller, Matthew P. Ho, Lai-Ming Tsang, Thomas Lo, Su-Vui Louie, Marie Leung, Gabriel M. Am J Med Article OBJECTIVE: Ribavirin and corticosteroids were used widely as front-line treatments for severe acute respiratory syndrome; however, previous evaluations were inconclusive. We assessed the effectiveness of ribavirin and corticosteroids as the initial treatment for severe acute respiratory syndrome using propensity score analysis. METHODS: We analyzed data on 1755 patients in Hong Kong and 191 patients in Toronto with severe acute respiratory syndrome using a generalized propensity score approach. RESULTS: The adjusted excess case fatality ratios of patients with severe acute respiratory syndrome receiving the combined therapy of ribavirin and corticosteroids within 2 days of admission, compared with those receiving neither treatment within 2 days of admission, were 3.8% (95% confidence interval, −1.5 to 9.2) in Hong Kong and 2.1% (95% confidence interval, −44.3 to 48.5) in Toronto. CONCLUSIONS: Our results add strength to the hypothesis that the combination of ribavirin and corticosteroids has no therapeutic benefit when given early during severe acute respiratory syndrome infection. Further studies may investigate the effects of these treatments later in disease course. Elsevier Inc. 2009-12 2009-12-02 /pmc/articles/PMC7093860/ /pubmed/19958895 http://dx.doi.org/10.1016/j.amjmed.2009.07.018 Text en Copyright © 2009 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Lau, Eric H.Y. Cowling, Benjamin J. Muller, Matthew P. Ho, Lai-Ming Tsang, Thomas Lo, Su-Vui Louie, Marie Leung, Gabriel M. Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome |
title | Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome |
title_full | Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome |
title_fullStr | Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome |
title_full_unstemmed | Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome |
title_short | Effectiveness of Ribavirin and Corticosteroids for Severe Acute Respiratory Syndrome |
title_sort | effectiveness of ribavirin and corticosteroids for severe acute respiratory syndrome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093860/ https://www.ncbi.nlm.nih.gov/pubmed/19958895 http://dx.doi.org/10.1016/j.amjmed.2009.07.018 |
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