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Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome

PURPOSE: To determine whether the initial chest radiograph is helpful in predicting the clinical outcome of patients with severe acute respiratory syndrome (SARS). METHODS: Of 343 patients who met the World Health Organization’s case definition of probable SARS and who had been admitted to a regiona...

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Autores principales: Chau, Tai-nin, Lee, Po-oi, Choi, Kin-wing, Lee, Chiu-man, Ma, Ka-fai, Tsang, Tak-yin, Tso, Yuk-keung, Chiu, Ming-chee, Tong, Wing-lok, Yu, Wai-cho, Lai, Sik-to
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093886/
https://www.ncbi.nlm.nih.gov/pubmed/15308434
http://dx.doi.org/10.1016/j.amjmed.2004.03.020
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author Chau, Tai-nin
Lee, Po-oi
Choi, Kin-wing
Lee, Chiu-man
Ma, Ka-fai
Tsang, Tak-yin
Tso, Yuk-keung
Chiu, Ming-chee
Tong, Wing-lok
Yu, Wai-cho
Lai, Sik-to
author_facet Chau, Tai-nin
Lee, Po-oi
Choi, Kin-wing
Lee, Chiu-man
Ma, Ka-fai
Tsang, Tak-yin
Tso, Yuk-keung
Chiu, Ming-chee
Tong, Wing-lok
Yu, Wai-cho
Lai, Sik-to
author_sort Chau, Tai-nin
collection PubMed
description PURPOSE: To determine whether the initial chest radiograph is helpful in predicting the clinical outcome of patients with severe acute respiratory syndrome (SARS). METHODS: Of 343 patients who met the World Health Organization’s case definition of probable SARS and who had been admitted to a regional hospital in Hong Kong, 201 patients had laboratory evidence of SARS coronavirus infection. The initial frontal chest radiographs of these 201 patients were assessed in a blinded fashion by 3 radiologists; individual findings were accepted if at least 2 of the radiologists concurred. Independent predictors of an adverse outcome, defined as the need for assisted ventilation, death, or both, were identified by multivariate analysis. RESULTS: Bilateral disease and involvement of more than two zones on the initial chest radiograph were associated with a higher risk of liver impairment and poor clinical outcome. Forty-two patients (21%) developed an adverse outcome. Multivariate analysis showed that lung involvement of more than two zones (odds ratio [OR] = 7.0; 95% confidence interval [CI]: 2.7 to 17.9), older age (OR for each decade of life = 1.5; 95% CI: 1.1 to 2.0), and shortness of breath on admission (OR = 2.8; 95% CI: 1.1 to 7.4) were independent predictors of an adverse outcome. CONCLUSION: Frontal chest radiographs on presentation may have prognostic value in patients with SARS.
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spelling pubmed-70938862020-03-25 Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome Chau, Tai-nin Lee, Po-oi Choi, Kin-wing Lee, Chiu-man Ma, Ka-fai Tsang, Tak-yin Tso, Yuk-keung Chiu, Ming-chee Tong, Wing-lok Yu, Wai-cho Lai, Sik-to Am J Med Article PURPOSE: To determine whether the initial chest radiograph is helpful in predicting the clinical outcome of patients with severe acute respiratory syndrome (SARS). METHODS: Of 343 patients who met the World Health Organization’s case definition of probable SARS and who had been admitted to a regional hospital in Hong Kong, 201 patients had laboratory evidence of SARS coronavirus infection. The initial frontal chest radiographs of these 201 patients were assessed in a blinded fashion by 3 radiologists; individual findings were accepted if at least 2 of the radiologists concurred. Independent predictors of an adverse outcome, defined as the need for assisted ventilation, death, or both, were identified by multivariate analysis. RESULTS: Bilateral disease and involvement of more than two zones on the initial chest radiograph were associated with a higher risk of liver impairment and poor clinical outcome. Forty-two patients (21%) developed an adverse outcome. Multivariate analysis showed that lung involvement of more than two zones (odds ratio [OR] = 7.0; 95% confidence interval [CI]: 2.7 to 17.9), older age (OR for each decade of life = 1.5; 95% CI: 1.1 to 2.0), and shortness of breath on admission (OR = 2.8; 95% CI: 1.1 to 7.4) were independent predictors of an adverse outcome. CONCLUSION: Frontal chest radiographs on presentation may have prognostic value in patients with SARS. Elsevier Inc. 2004-08-15 2004-08-10 /pmc/articles/PMC7093886/ /pubmed/15308434 http://dx.doi.org/10.1016/j.amjmed.2004.03.020 Text en Copyright © 2004 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Chau, Tai-nin
Lee, Po-oi
Choi, Kin-wing
Lee, Chiu-man
Ma, Ka-fai
Tsang, Tak-yin
Tso, Yuk-keung
Chiu, Ming-chee
Tong, Wing-lok
Yu, Wai-cho
Lai, Sik-to
Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome
title Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome
title_full Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome
title_fullStr Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome
title_full_unstemmed Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome
title_short Value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome
title_sort value of initial chest radiographs for predicting clinical outcomes in patients with severe acute respiratory syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093886/
https://www.ncbi.nlm.nih.gov/pubmed/15308434
http://dx.doi.org/10.1016/j.amjmed.2004.03.020
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