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Double negative T cells, a potential biomarker for systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease that is a challenge to diagnose and treat. There is an urgent need for biomarkers to help define organ involvement, and more effective therapies. A unique population of T cells, the CD3(+)CD4(−)CD8(−) (DNeg) cells, is significantly increase...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093895/ https://www.ncbi.nlm.nih.gov/pubmed/32257532 http://dx.doi.org/10.1093/pcmedi/pbaa001 |
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author | Alexander, Jessy J Jacob, Alexander Chang, Anthony Quigg, Richard J Jarvis, James N |
author_facet | Alexander, Jessy J Jacob, Alexander Chang, Anthony Quigg, Richard J Jarvis, James N |
author_sort | Alexander, Jessy J |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is an autoimmune disease that is a challenge to diagnose and treat. There is an urgent need for biomarkers to help define organ involvement, and more effective therapies. A unique population of T cells, the CD3(+)CD4(−)CD8(−) (DNeg) cells, is significantly increased in lupus patients. Twenty-seven cases (53%) of pediatric SLE patients had elevated DNeg cells in their peripheral blood, which correlated with kidney function (R(2) = 0.54). Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by immunofluorescence. For the first time, this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus mice. In lupus mice, the increase in DNeg cells tracked with worsening disease and correlated with kidney function (R(2) = 0.85). Our results show that DNeg cells per se can cause kidney dysfunction, increase in number with increase in disease pathology, and could serve as a potential biomarker. |
format | Online Article Text |
id | pubmed-7093895 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-70938952020-03-30 Double negative T cells, a potential biomarker for systemic lupus erythematosus Alexander, Jessy J Jacob, Alexander Chang, Anthony Quigg, Richard J Jarvis, James N Precis Clin Med Research Article Systemic lupus erythematosus (SLE) is an autoimmune disease that is a challenge to diagnose and treat. There is an urgent need for biomarkers to help define organ involvement, and more effective therapies. A unique population of T cells, the CD3(+)CD4(−)CD8(−) (DNeg) cells, is significantly increased in lupus patients. Twenty-seven cases (53%) of pediatric SLE patients had elevated DNeg cells in their peripheral blood, which correlated with kidney function (R(2) = 0.54). Significant infiltration of DNeg cells was observed in both adult and pediatric lupus kidneys by immunofluorescence. For the first time, this study provides direct evidence that DNeg cells facilitate kidney injury in preclinical 8-week-old MRL/lpr lupus mice. In lupus mice, the increase in DNeg cells tracked with worsening disease and correlated with kidney function (R(2) = 0.85). Our results show that DNeg cells per se can cause kidney dysfunction, increase in number with increase in disease pathology, and could serve as a potential biomarker. Oxford University Press 2020-03 2020-01-20 /pmc/articles/PMC7093895/ /pubmed/32257532 http://dx.doi.org/10.1093/pcmedi/pbaa001 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of West China School of Medicine & West China Hospital of Sichuan University. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Research Article Alexander, Jessy J Jacob, Alexander Chang, Anthony Quigg, Richard J Jarvis, James N Double negative T cells, a potential biomarker for systemic lupus erythematosus |
title | Double negative T cells, a potential biomarker for systemic lupus erythematosus |
title_full | Double negative T cells, a potential biomarker for systemic lupus erythematosus |
title_fullStr | Double negative T cells, a potential biomarker for systemic lupus erythematosus |
title_full_unstemmed | Double negative T cells, a potential biomarker for systemic lupus erythematosus |
title_short | Double negative T cells, a potential biomarker for systemic lupus erythematosus |
title_sort | double negative t cells, a potential biomarker for systemic lupus erythematosus |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093895/ https://www.ncbi.nlm.nih.gov/pubmed/32257532 http://dx.doi.org/10.1093/pcmedi/pbaa001 |
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