Disruption of cholinergic neurotransmission, within a cognitive challenge paradigm, is indicative of Aβ-related cognitive impairment in preclinical Alzheimer’s disease after a 27-month delay interval

BACKGROUND: Abnormal beta-amyloid (Aβ) is associated with deleterious changes in central cholinergic tone in the very early stages of Alzheimer’s disease (AD), which may be unmasked by a cholinergic antagonist (J Prev Alzheimers Dis 1:1–4, 2017). Previously, we established the scopolamine challenge...

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Detalles Bibliográficos
Autores principales: Alber, Jessica, Maruff, Paul, Santos, Cláudia Y., Ott, Brian R., Salloway, Stephen P., Yoo, Don C., Noto, Richard B., Thompson, Louisa I., Goldfarb, Danielle, Arthur, Edmund, Song, Alex, Snyder, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093953/
https://www.ncbi.nlm.nih.gov/pubmed/32209123
http://dx.doi.org/10.1186/s13195-020-00599-1

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