Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum

INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. METHODS: In...

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Autores principales: Palma, Adalid, Matamoros, Gabriela, Escobar, Denis, Sánchez, Ana Lourdes, Fontecha, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094045/
https://www.ncbi.nlm.nih.gov/pubmed/32187331
http://dx.doi.org/10.1590/0037-8682-0155-2019
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author Palma, Adalid
Matamoros, Gabriela
Escobar, Denis
Sánchez, Ana Lourdes
Fontecha, Gustavo
author_facet Palma, Adalid
Matamoros, Gabriela
Escobar, Denis
Sánchez, Ana Lourdes
Fontecha, Gustavo
author_sort Palma, Adalid
collection PubMed
description INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. METHODS: In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced. RESULTS: All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene. CONCLUSIONS: This is the first report of genetic sequences associated with benzimidazole resistance in A. suum.
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spelling pubmed-70940452020-03-25 Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum Palma, Adalid Matamoros, Gabriela Escobar, Denis Sánchez, Ana Lourdes Fontecha, Gustavo Rev Soc Bras Med Trop Short Communication INTRODUCTION: Benzimidazoles are commonly used for the control of veterinary nematodes. Resistance to benzimidazoles has been associated with three single nucleotide polymorphisms in the β-tubulin gene of common nematodes. However, these mutations are infrequent in the genus Ascaris spp. METHODS: In order to determine mutations associated with benzimidazole resistance in Ascaris suum, worms were collected from slaughtered pigs and a partial region of the β-tubulin gene was sequenced. RESULTS: All parasites showed the wildtype genotype for codons 167, 198, and 200 of the β-tubulin gene. CONCLUSIONS: This is the first report of genetic sequences associated with benzimidazole resistance in A. suum. Sociedade Brasileira de Medicina Tropical - SBMT 2020-03-16 /pmc/articles/PMC7094045/ /pubmed/32187331 http://dx.doi.org/10.1590/0037-8682-0155-2019 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Palma, Adalid
Matamoros, Gabriela
Escobar, Denis
Sánchez, Ana Lourdes
Fontecha, Gustavo
Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
title Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
title_full Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
title_fullStr Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
title_full_unstemmed Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
title_short Absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of Ascaris suum
title_sort absence of mutations associated with resistance to benzimidazole in the beta-tubulin gene of ascaris suum
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094045/
https://www.ncbi.nlm.nih.gov/pubmed/32187331
http://dx.doi.org/10.1590/0037-8682-0155-2019
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