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Molecular dynamic simulations analysis of ritronavir and lopinavir as SARS-CoV 3CL(pro) inhibitors

Since the emergence of the severe acute respiratory syndrome (SARS) to date, neither an effective antiviral drug nor a vaccine against SARS is available. However, it was found that a mixture of two HIV-1 proteinase inhibitors, lopinavir and ritonavir, exhibited some signs of effectiveness against th...

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Detalles Bibliográficos
Autores principales:	Nukoolkarn, Veena, Lee, Vannajan Sanghiran, Malaisree, Maturos, Aruksakulwong, Ornjira, Hannongbua, Supot
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094092/ https://www.ncbi.nlm.nih.gov/pubmed/18706430 http://dx.doi.org/10.1016/j.jtbi.2008.07.030

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