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Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment

BACKGROUND: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side...

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Autores principales: Wang, Ji, Wu, Xia, Shen, Peng, Wang, Jun, Shen, Yidan, Shen, Yan, Webster, Thomas J, Deng, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094149/
https://www.ncbi.nlm.nih.gov/pubmed/32256067
http://dx.doi.org/10.2147/IJN.S239751
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author Wang, Ji
Wu, Xia
Shen, Peng
Wang, Jun
Shen, Yidan
Shen, Yan
Webster, Thomas J
Deng, Junjie
author_facet Wang, Ji
Wu, Xia
Shen, Peng
Wang, Jun
Shen, Yidan
Shen, Yan
Webster, Thomas J
Deng, Junjie
author_sort Wang, Ji
collection PubMed
description BACKGROUND: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions. METHODS: In this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS(2)QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy. RESULTS: This review found much evidence for the use of inorganic nanoparticles for PTT-based combinational cancer therapy. CONCLUSION: Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field.
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spelling pubmed-70941492020-04-01 Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment Wang, Ji Wu, Xia Shen, Peng Wang, Jun Shen, Yidan Shen, Yan Webster, Thomas J Deng, Junjie Int J Nanomedicine Review BACKGROUND: Cancer is one of the major causes of death and is difficult to cure using existing clinical therapies. Clinical cancer treatments [such as surgery, chemotherapy (CHT), radiotherapy (RT) and immunotherapy (IT)] are widely used but they have limited therapeutic effects and unavoidable side effects. Recently, the development of novel nanomaterials offers a platform for combinational therapy (meaning a combination of two or more therapeutic agents) which is a promising approach for cancer therapy. Recent studies have demonstrated several types of nanomaterials suitable for photothermal therapy (PTT) based on a near-infrared (NIR) light-responsive system. PTT possesses favorable properties such as being low in cost, and having high temporospatial control with minimal invasiveness. However, short NIR light penetration depth limits its functions. METHODS: In this review, due to their promise, we focus on inorganic nanomaterials [such as hollow mesoporous silica nanoparticles (HMSNs), tungsten sulfide quantum dots (WS(2)QDs), and gold nanorods (AuNRs)] combining PTT with CHT, RT or IT in one treatment, aiming to provide a comprehensive understanding of PTT-based combinational cancer therapy. RESULTS: This review found much evidence for the use of inorganic nanoparticles for PTT-based combinational cancer therapy. CONCLUSION: Under synergistic effects, inorganic nanomaterial-based combinational treatments exhibit enhanced therapeutic effects compared to PTT, CHT, RT, IT or PDT alone and should be further investigated in the cancer field. Dove 2020-03-19 /pmc/articles/PMC7094149/ /pubmed/32256067 http://dx.doi.org/10.2147/IJN.S239751 Text en © 2020 Wang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Wang, Ji
Wu, Xia
Shen, Peng
Wang, Jun
Shen, Yidan
Shen, Yan
Webster, Thomas J
Deng, Junjie
Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment
title Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment
title_full Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment
title_fullStr Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment
title_full_unstemmed Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment
title_short Applications of Inorganic Nanomaterials in Photothermal Therapy Based on Combinational Cancer Treatment
title_sort applications of inorganic nanomaterials in photothermal therapy based on combinational cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094149/
https://www.ncbi.nlm.nih.gov/pubmed/32256067
http://dx.doi.org/10.2147/IJN.S239751
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