Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus

Vaccination of dams with modified-live canine distemper virus (CDV) vaccines will elicit high concentrations of colostral antibody, that although vital for protection of the pup during the first weeks of life, can interfere with active vaccination against the virus. In the present study, 12 pups, 7–...

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Detalles Bibliográficos
Autores principales: Pardo, M.C., Tanner, P., Bauman, J., Silver, K., Fischer, L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094307/
https://www.ncbi.nlm.nih.gov/pubmed/17560592
http://dx.doi.org/10.1016/j.jcpa.2007.04.015
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author Pardo, M.C.
Tanner, P.
Bauman, J.
Silver, K.
Fischer, L.
author_facet Pardo, M.C.
Tanner, P.
Bauman, J.
Silver, K.
Fischer, L.
author_sort Pardo, M.C.
collection PubMed
description Vaccination of dams with modified-live canine distemper virus (CDV) vaccines will elicit high concentrations of colostral antibody, that although vital for protection of the pup during the first weeks of life, can interfere with active vaccination against the virus. In the present study, 12 pups, 7–9 weeks of age, with maternally derived immunity to CDV, were vaccinated with a canarypox-vectored CDV vaccine. These pups were protected against intravenous challenge with CDV. Three littermate pups that were unvaccinated all developed clinical signs of infection after challenge, and two of these control pups died.
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spelling pubmed-70943072020-03-25 Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus Pardo, M.C. Tanner, P. Bauman, J. Silver, K. Fischer, L. J Comp Pathol Article Vaccination of dams with modified-live canine distemper virus (CDV) vaccines will elicit high concentrations of colostral antibody, that although vital for protection of the pup during the first weeks of life, can interfere with active vaccination against the virus. In the present study, 12 pups, 7–9 weeks of age, with maternally derived immunity to CDV, were vaccinated with a canarypox-vectored CDV vaccine. These pups were protected against intravenous challenge with CDV. Three littermate pups that were unvaccinated all developed clinical signs of infection after challenge, and two of these control pups died. Elsevier Ltd. 2007-07 2007-06-08 /pmc/articles/PMC7094307/ /pubmed/17560592 http://dx.doi.org/10.1016/j.jcpa.2007.04.015 Text en Copyright © 2007 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pardo, M.C.
Tanner, P.
Bauman, J.
Silver, K.
Fischer, L.
Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus
title Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus
title_full Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus
title_fullStr Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus
title_full_unstemmed Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus
title_short Immunization of Puppies in the Presence of Maternally Derived Antibodies Against Canine Distemper Virus
title_sort immunization of puppies in the presence of maternally derived antibodies against canine distemper virus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094307/
https://www.ncbi.nlm.nih.gov/pubmed/17560592
http://dx.doi.org/10.1016/j.jcpa.2007.04.015
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