Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase

The SARS coronavirus main peptidase (SARS-CoV M(pro)) plays an essential role in the life-cycle of the virus and is a primary target for the development of anti-SARS agents. Here, we report the crystal structure of M(pro) at a resolution of 1.82 Å, in space group P2(1) at pH 6.0. In contrast to the...

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Detalles Bibliográficos
Autores principales: Lee, Ting-Wai, Cherney, Maia M., Liu, Jie, James, Karen Ellis, Powers, James C., Eltis, Lindsay D., James, Michael N.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094323/
https://www.ncbi.nlm.nih.gov/pubmed/17196984
http://dx.doi.org/10.1016/j.jmb.2006.11.078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094323/
https://www.ncbi.nlm.nih.gov/pubmed/17196984
http://dx.doi.org/10.1016/j.jmb.2006.11.078

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