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Crystallographic Analysis of the Reaction Cycle of 2′,3′-Cyclic Nucleotide 3′-Phosphodiesterase, a Unique Member of the 2H Phosphoesterase Family

2H phosphoesterases catalyze reactions on nucleotide substrates and contain two conserved histidine residues in the active site. Very limited information is currently available on the details of the active site and substrate/product binding during the catalytic cycle of these enzymes. We performed a...

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Detalles Bibliográficos
Autores principales: Myllykoski, Matti, Raasakka, Arne, Lehtimäki, Mari, Han, Huijong, Kursula, Inari, Kursula, Petri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094350/
https://www.ncbi.nlm.nih.gov/pubmed/23831225
http://dx.doi.org/10.1016/j.jmb.2013.06.012