Vaccines for the Elderly: The Quest for the Ideal Animal Model

A decline in protective immune responses following vaccination is one of the main features of immunosenescence. Improved vaccine candidates for elderly adults are thus urgently needed. For scientific and regulatory requirements, such new vaccines must first be evaluated at the preclinical level, and...

Descripción completa

Detalles Bibliográficos
Autor principal: Boudet, F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094446/
https://www.ncbi.nlm.nih.gov/pubmed/19897204
http://dx.doi.org/10.1016/j.jcpa.2009.10.005
_version_ 1783510472233844736
author Boudet, F.
author_facet Boudet, F.
author_sort Boudet, F.
collection PubMed
description A decline in protective immune responses following vaccination is one of the main features of immunosenescence. Improved vaccine candidates for elderly adults are thus urgently needed. For scientific and regulatory requirements, such new vaccines must first be evaluated at the preclinical level, and there is a continuing quest for the ideal animal model with which to perform such studies. The main advantages and limitations of murine models, those most commonly used for human vaccine research, and of large animal models are reviewed and discussed.
format Online
Article
Text
id pubmed-7094446
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Elsevier Ltd.
record_format MEDLINE/PubMed
spelling pubmed-70944462020-03-25 Vaccines for the Elderly: The Quest for the Ideal Animal Model Boudet, F. J Comp Pathol Article A decline in protective immune responses following vaccination is one of the main features of immunosenescence. Improved vaccine candidates for elderly adults are thus urgently needed. For scientific and regulatory requirements, such new vaccines must first be evaluated at the preclinical level, and there is a continuing quest for the ideal animal model with which to perform such studies. The main advantages and limitations of murine models, those most commonly used for human vaccine research, and of large animal models are reviewed and discussed. Elsevier Ltd. 2010-01 2009-11-07 /pmc/articles/PMC7094446/ /pubmed/19897204 http://dx.doi.org/10.1016/j.jcpa.2009.10.005 Text en Copyright © 2009 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Boudet, F.
Vaccines for the Elderly: The Quest for the Ideal Animal Model
title Vaccines for the Elderly: The Quest for the Ideal Animal Model
title_full Vaccines for the Elderly: The Quest for the Ideal Animal Model
title_fullStr Vaccines for the Elderly: The Quest for the Ideal Animal Model
title_full_unstemmed Vaccines for the Elderly: The Quest for the Ideal Animal Model
title_short Vaccines for the Elderly: The Quest for the Ideal Animal Model
title_sort vaccines for the elderly: the quest for the ideal animal model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094446/
https://www.ncbi.nlm.nih.gov/pubmed/19897204
http://dx.doi.org/10.1016/j.jcpa.2009.10.005
work_keys_str_mv AT boudetf vaccinesfortheelderlythequestfortheidealanimalmodel

Ejemplares similares