Production of Authentic SARS-CoV M(pro) with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction

The viral proteases have proven to be the most selective and useful for removing the fusion tags in fusion protein expression systems. As a key enzyme in the viral life-cycle, the main protease (M(pro)) is most attractive for drug design targeting the SARS coronavirus (SARS-CoV), the etiological age...

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Detalles Bibliográficos
Autores principales: Xue, Xiaoyu, Yang, Haitao, Shen, Wei, Zhao, Qi, Li, Jun, Yang, Kailin, Chen, Cheng, Jin, Yinghua, Bartlam, Mark, Rao, Zihe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094453/
https://www.ncbi.nlm.nih.gov/pubmed/17189639
http://dx.doi.org/10.1016/j.jmb.2006.11.073

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