Cargando…

pH-dependent Conformational Flexibility of the SARS-CoV Main Proteinase (M(pro)) Dimer: Molecular Dynamics Simulations and Multiple X-ray Structure Analyses

The SARS coronavirus main proteinase (M(pro)) is a key enzyme in the processing of the viral polyproteins and thus an attractive target for the discovery of drugs directed against SARS. The enzyme has been shown by X-ray crystallography to undergo significant pH-dependent conformational changes. Her...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Jinzhi, Verschueren, Koen H.G., Anand, Kanchan, Shen, Jianhua, Yang, Maojun, Xu, Yechun, Rao, Zihe, Bigalke, Janna, Heisen, Burkhard, Mesters, Jeroen R., Chen, Kaixian, Shen, Xu, Jiang, Hualiang, Hilgenfeld, Rolf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Ltd. 2005
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094468/ https://www.ncbi.nlm.nih.gov/pubmed/16242152 http://dx.doi.org/10.1016/j.jmb.2005.09.012

Ejemplares similares

Structure and Dynamics of Sars Coronavirus Main Proteinase (M(PRO))
por: Hilgenfeld, Rolf, et al.
Publicado: (2006)

A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters
por: Verschueren, Koen H.G., et al.
Publicado: (2008)

Coronavirus main proteinase: target for antiviral drug therapy
por: Anand, Kanchan, et al.
Publicado: (2005)

Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase N Terminus Is Indispensable for Proteolytic Activity but Not for Enzyme Dimerization: BIOCHEMICAL AND THERMODYNAMIC INVESTIGATION IN CONJUNCTION WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2005)

Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra α-helical domain
por: Anand, Kanchan, et al.
Publicado: (2002)

Enzymatic activity of the SARS coronavirus main proteinase dimer
por: Graziano, Vito, et al.
Publicado: (2006)

Structure of the SARS coronavirus main proteinase as an active C(2) crystallographic dimer
por: Xu, Ting, et al.
Publicado: (2005)

Viral enzymes
por: Mesters, Jeroen R, et al.
Publicado: (2006)

Mutation of Gly-11 on the Dimer Interface Results in the Complete Crystallographic Dimer Dissociation of Severe Acute Respiratory Syndrome Coronavirus 3C-like Protease: CRYSTAL STRUCTURE WITH MOLECULAR DYNAMICS SIMULATIONS
por: Chen, Shuai, et al.
Publicado: (2008)

Erratum to: Liberation of SARS-CoV main protease from the viral polyprotein: N-terminal autocleavage does not depend on the mature dimerization mode
por: Chen, Shuai, et al.
Publicado: (2010)

Prediction of potential inhibitors of the dimeric SARS-CoV2 main proteinase through the MM/GBSA approach
por: Bello, Martiniano
Publicado: (2020)

Expression, purification, and in vitro activity of an arterivirus main proteinase
por: van Aken, Danny, et al.
Publicado: (2006)

Generation of predictive pharmacophore model for SARS-coronavirus main proteinase
por: Zhang, Xue Wu, et al.
Publicado: (2005)

Homology models of main proteinase from coronavirus associated with SARS
por: Liu, Hsuan-Liang, et al.
Publicado: (2005)

SARS coronavirus main proteinase 3.4.22.69
por: Schomburg, Dietmar, et al.
Publicado: (2013)

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase
por: Xu, Yechun, et al.
Publicado: (2020)

Only One Protomer Is Active in the Dimer of SARS 3C-like Proteinase
por: Chen, Hao, et al.
Publicado: (2006)

Techniques used for the discovery of therapeutic compounds: The case of SARS
por: Chen, Shuai, et al.
Publicado: (2006)

Synthesis and activity of an octapeptide inhibitor designed for SARS coronavirus main proteinase
por: Gan, Yi-Ru, et al.
Publicado: (2006)

High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase
por: Blanchard, Jan E., et al.
Publicado: (2004)

Severe acute respiratory syndrome coronavirus membrane protein interacts with nucleocapsid protein mostly through their carboxyl termini by electrostatic attraction
por: Luo, Haibin, et al.
Publicado: (2006)

Improved synthesis of rupintrivir
por: Lin, DaiZong, et al.
Publicado: (2012)

Drug discovery and development targeting the life cycle of SARS-CoV-2
por: Su, Haixia, et al.
Publicado: (2021)

Lys169 of Human Glucokinase Is a Determinant for Glucose Phosphorylation: Implication for the Atomic Mechanism of Glucokinase Catalysis
por: Zhang, Jian, et al.
Publicado: (2009)

The nucleocapsid protein of SARS coronavirus has a high binding affinity to the human cellular heterogeneous nuclear ribonucleoprotein A1
por: Luo, Haibin, et al.
Publicado: (2005)

In Silico Drug Repurposing for SARS-CoV-2 Main Proteinase and Spike Proteins
por: Maffucci, Irene, et al.
Publicado: (2020)

In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2
por: Shang, Weijuan, et al.
Publicado: (2022)

The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase()
por: Wei, Ping, et al.
Publicado: (2006)

The SARS-Unique Domain (SUD) of SARS Coronavirus Contains Two Macrodomains That Bind G-Quadruplexes
por: Tan, Jinzhi, et al.
Publicado: (2009)

Proteinases in the joint: clinical relevance of proteinases in joint destruction
por: Rengel, Yvonne, et al.
Publicado: (2007)

Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS()
por: Chou, Kuo-Chen, et al.
Publicado: (2003)

Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors
por: Cui, Jiahua, et al.
Publicado: (2021)

Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A
por: Luo, Cheng, et al.
Publicado: (2004)

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease
por: Dai, Wenhao, et al.
Publicado: (2020)

High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors
por: Zang, Yi, et al.
Publicado: (2022)

C-terminal domain of SARS-CoV main protease can form a 3D domain-swapped dimer
por: Zhong, Nan, et al.
Publicado: (2009)

Variable Oligomerization Modes in Coronavirus Non-structural Protein 9
por: Ponnusamy, Rajesh, et al.
Publicado: (2008)

Non Structural Proteins 8 and 9 of Human Coronavirus 229E
por: Ponnusamy, Rajesh, et al.
Publicado: (2006)

Proteinases and Tumour Invasion
por: Schor, S.
Publicado: (1982)

Viral cysteine proteinases
por: Gorbalenya, Alexander E., et al.
Publicado: (1996)

Cannot write session to /tmp/vufind_sessions/sess_63gmn9nrekd0tesskqsj3l6qul