Cargando…

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal...

Descripción completa

Detalles Bibliográficos
Autores principales: Ohl, Kim, Tenbrock, Klaus, Kipp, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094520/
https://www.ncbi.nlm.nih.gov/pubmed/26626971
http://dx.doi.org/10.1016/j.expneurol.2015.11.010
_version_ 1783510488380866560
author Ohl, Kim
Tenbrock, Klaus
Kipp, Markus
author_facet Ohl, Kim
Tenbrock, Klaus
Kipp, Markus
author_sort Ohl, Kim
collection PubMed
description Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal models. One of the most studied cell populations in the context of ROS-mediated tissue damage in MS are macrophages and their CNS companion, microglia cells. However, and this aspect is less well appreciated, the extracellular and intracellular redox milieu is integral to many processes underlying T cell activation, proliferation and apoptosis. In this review article we discuss how oxidative stress affects central as well as peripheral aspects of MS and how manipulation of ROS pathways can potentially affect the course of the disease. It is our strong belief that the well-directed shaping of ROS pathways has the potential to ameliorate disease progression in MS.
format Online
Article
Text
id pubmed-7094520
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-70945202020-03-25 Oxidative stress in multiple sclerosis: Central and peripheral mode of action Ohl, Kim Tenbrock, Klaus Kipp, Markus Exp Neurol Article Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal models. One of the most studied cell populations in the context of ROS-mediated tissue damage in MS are macrophages and their CNS companion, microglia cells. However, and this aspect is less well appreciated, the extracellular and intracellular redox milieu is integral to many processes underlying T cell activation, proliferation and apoptosis. In this review article we discuss how oxidative stress affects central as well as peripheral aspects of MS and how manipulation of ROS pathways can potentially affect the course of the disease. It is our strong belief that the well-directed shaping of ROS pathways has the potential to ameliorate disease progression in MS. Elsevier Inc. 2016-03 2015-11-26 /pmc/articles/PMC7094520/ /pubmed/26626971 http://dx.doi.org/10.1016/j.expneurol.2015.11.010 Text en Copyright © 2015 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Ohl, Kim
Tenbrock, Klaus
Kipp, Markus
Oxidative stress in multiple sclerosis: Central and peripheral mode of action
title Oxidative stress in multiple sclerosis: Central and peripheral mode of action
title_full Oxidative stress in multiple sclerosis: Central and peripheral mode of action
title_fullStr Oxidative stress in multiple sclerosis: Central and peripheral mode of action
title_full_unstemmed Oxidative stress in multiple sclerosis: Central and peripheral mode of action
title_short Oxidative stress in multiple sclerosis: Central and peripheral mode of action
title_sort oxidative stress in multiple sclerosis: central and peripheral mode of action
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094520/
https://www.ncbi.nlm.nih.gov/pubmed/26626971
http://dx.doi.org/10.1016/j.expneurol.2015.11.010
work_keys_str_mv AT ohlkim oxidativestressinmultiplesclerosiscentralandperipheralmodeofaction
AT tenbrockklaus oxidativestressinmultiplesclerosiscentralandperipheralmodeofaction
AT kippmarkus oxidativestressinmultiplesclerosiscentralandperipheralmodeofaction