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Oxidative stress in multiple sclerosis: Central and peripheral mode of action
Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094520/ https://www.ncbi.nlm.nih.gov/pubmed/26626971 http://dx.doi.org/10.1016/j.expneurol.2015.11.010 |
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author | Ohl, Kim Tenbrock, Klaus Kipp, Markus |
author_facet | Ohl, Kim Tenbrock, Klaus Kipp, Markus |
author_sort | Ohl, Kim |
collection | PubMed |
description | Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal models. One of the most studied cell populations in the context of ROS-mediated tissue damage in MS are macrophages and their CNS companion, microglia cells. However, and this aspect is less well appreciated, the extracellular and intracellular redox milieu is integral to many processes underlying T cell activation, proliferation and apoptosis. In this review article we discuss how oxidative stress affects central as well as peripheral aspects of MS and how manipulation of ROS pathways can potentially affect the course of the disease. It is our strong belief that the well-directed shaping of ROS pathways has the potential to ameliorate disease progression in MS. |
format | Online Article Text |
id | pubmed-7094520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70945202020-03-25 Oxidative stress in multiple sclerosis: Central and peripheral mode of action Ohl, Kim Tenbrock, Klaus Kipp, Markus Exp Neurol Article Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead to oxidative stress, have been implicated as mediators of demyelination and axonal damage in both MS and its animal models. One of the most studied cell populations in the context of ROS-mediated tissue damage in MS are macrophages and their CNS companion, microglia cells. However, and this aspect is less well appreciated, the extracellular and intracellular redox milieu is integral to many processes underlying T cell activation, proliferation and apoptosis. In this review article we discuss how oxidative stress affects central as well as peripheral aspects of MS and how manipulation of ROS pathways can potentially affect the course of the disease. It is our strong belief that the well-directed shaping of ROS pathways has the potential to ameliorate disease progression in MS. Elsevier Inc. 2016-03 2015-11-26 /pmc/articles/PMC7094520/ /pubmed/26626971 http://dx.doi.org/10.1016/j.expneurol.2015.11.010 Text en Copyright © 2015 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Ohl, Kim Tenbrock, Klaus Kipp, Markus Oxidative stress in multiple sclerosis: Central and peripheral mode of action |
title | Oxidative stress in multiple sclerosis: Central and peripheral mode of action |
title_full | Oxidative stress in multiple sclerosis: Central and peripheral mode of action |
title_fullStr | Oxidative stress in multiple sclerosis: Central and peripheral mode of action |
title_full_unstemmed | Oxidative stress in multiple sclerosis: Central and peripheral mode of action |
title_short | Oxidative stress in multiple sclerosis: Central and peripheral mode of action |
title_sort | oxidative stress in multiple sclerosis: central and peripheral mode of action |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094520/ https://www.ncbi.nlm.nih.gov/pubmed/26626971 http://dx.doi.org/10.1016/j.expneurol.2015.11.010 |
work_keys_str_mv | AT ohlkim oxidativestressinmultiplesclerosiscentralandperipheralmodeofaction AT tenbrockklaus oxidativestressinmultiplesclerosiscentralandperipheralmodeofaction AT kippmarkus oxidativestressinmultiplesclerosiscentralandperipheralmodeofaction |