Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide

The main peptidase (M(pro)) from the coronavirus (CoV) causing severe acute respiratory syndrome (SARS) is one of the most attractive molecular targets for the development of anti-SARS agents. We report the irreversible inhibition of SARS-CoV M(pro) by an aza-peptide epoxide (APE; k(inact)/K(i)=1900...

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Detalles Bibliográficos
Autores principales: Lee, Ting-Wai, Cherney, Maia M., Huitema, Carly, Liu, Jie, James, Karen Ellis, Powers, James C., Eltis, Lindsay D., James, Michael N.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2005
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094542/
https://www.ncbi.nlm.nih.gov/pubmed/16219322
http://dx.doi.org/10.1016/j.jmb.2005.09.004

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