Profiling the IgOme: Meeting the challenge()

The entire repertoire of antibodies in our serum, the IgOme, is a historical record of our past experiences and a reflection of our immune status at any given moment. Understanding the dynamics of the IgOme and how the diversity and specificities of serum antibodies change in response to disease and...

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Detalles Bibliográficos
Autores principales: Weiss-Ottolenghi, Yael, Gershoni, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of European Biochemical Societies. Published by Elsevier B.V. 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094557/
https://www.ncbi.nlm.nih.gov/pubmed/24239539
http://dx.doi.org/10.1016/j.febslet.2013.11.005
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author Weiss-Ottolenghi, Yael
Gershoni, Jonathan M.
author_facet Weiss-Ottolenghi, Yael
Gershoni, Jonathan M.
author_sort Weiss-Ottolenghi, Yael
collection PubMed
description The entire repertoire of antibodies in our serum, the IgOme, is a historical record of our past experiences and a reflection of our immune status at any given moment. Understanding the dynamics of the IgOme and how the diversity and specificities of serum antibodies change in response to disease and maintenance of homeostasis can directly impact the ability to design and develop novel vaccines, diagnostics and therapeutics. Here we review both direct and indirect methodologies that are being developed to map the complexity and specificities of the antibodies in polyclonal serum – the IgOme.
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spelling pubmed-70945572020-03-25 Profiling the IgOme: Meeting the challenge() Weiss-Ottolenghi, Yael Gershoni, Jonathan M. FEBS Lett Review The entire repertoire of antibodies in our serum, the IgOme, is a historical record of our past experiences and a reflection of our immune status at any given moment. Understanding the dynamics of the IgOme and how the diversity and specificities of serum antibodies change in response to disease and maintenance of homeostasis can directly impact the ability to design and develop novel vaccines, diagnostics and therapeutics. Here we review both direct and indirect methodologies that are being developed to map the complexity and specificities of the antibodies in polyclonal serum – the IgOme. Federation of European Biochemical Societies. Published by Elsevier B.V. 2014-01-21 2013-11-12 /pmc/articles/PMC7094557/ /pubmed/24239539 http://dx.doi.org/10.1016/j.febslet.2013.11.005 Text en Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Weiss-Ottolenghi, Yael
Gershoni, Jonathan M.
Profiling the IgOme: Meeting the challenge()
title Profiling the IgOme: Meeting the challenge()
title_full Profiling the IgOme: Meeting the challenge()
title_fullStr Profiling the IgOme: Meeting the challenge()
title_full_unstemmed Profiling the IgOme: Meeting the challenge()
title_short Profiling the IgOme: Meeting the challenge()
title_sort profiling the igome: meeting the challenge()
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094557/
https://www.ncbi.nlm.nih.gov/pubmed/24239539
http://dx.doi.org/10.1016/j.febslet.2013.11.005
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