Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome‐associated coronavirus

SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS...

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Detalles Bibliográficos
Autores principales: Law, Pui Ying Peggy, Liu, Yuet-Man, Geng, Hua, Kwan, Ka Ho, Waye, Mary Miu-Yee, Ho, Yuan-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2006
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094570/
https://www.ncbi.nlm.nih.gov/pubmed/16753150
http://dx.doi.org/10.1016/j.febslet.2006.05.051
Descripción
Sumario:SARS 8b is one of the putative accessory proteins of the severe acute respiratory syndrome‐associated coronavirus (SARS‐CoV) with unknown functions. In this study, the cellular localization and activity of this estimated 9.6 kDa protein were examined. Confocal microscopy results indicated that SARS 8b is localized in both nucleus and cytoplasm of mammalian cells. Functional study revealed that overexpression of SARS 8b induced DNA synthesis. Coexpression of SARS 8b and SARS 6, a previously characterized SARS‐CoV accessory protein, did not elicit synergistic effects on DNA synthesis.

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