Viral proteins function as ion channels

Viral ion channels are short membrane proteins with 50–120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the rece...

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Detalles Bibliográficos
Autores principales: Wang, Kai, Xie, Shiqi, Sun, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094589/
https://www.ncbi.nlm.nih.gov/pubmed/20478263
http://dx.doi.org/10.1016/j.bbamem.2010.05.006
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author Wang, Kai
Xie, Shiqi
Sun, Bing
author_facet Wang, Kai
Xie, Shiqi
Sun, Bing
author_sort Wang, Kai
collection PubMed
description Viral ion channels are short membrane proteins with 50–120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the recent advances in viral encoded ion channel proteins (or viroporins), including PBCV-1 KcV, influenza M2, HIV-1 Vpu, HCV p7, picornavirus 2B, and coronavirus E and 3a. We focus on their function and mechanisms, and also discuss viral ion channel protein serving as a potential drug target.
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spelling pubmed-70945892020-03-25 Viral proteins function as ion channels Wang, Kai Xie, Shiqi Sun, Bing Biochim Biophys Acta Biomembr Review Viral ion channels are short membrane proteins with 50–120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the recent advances in viral encoded ion channel proteins (or viroporins), including PBCV-1 KcV, influenza M2, HIV-1 Vpu, HCV p7, picornavirus 2B, and coronavirus E and 3a. We focus on their function and mechanisms, and also discuss viral ion channel protein serving as a potential drug target. Elsevier B.V. 2011-02 2010-05-15 /pmc/articles/PMC7094589/ /pubmed/20478263 http://dx.doi.org/10.1016/j.bbamem.2010.05.006 Text en Copyright © 2010 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Wang, Kai
Xie, Shiqi
Sun, Bing
Viral proteins function as ion channels
title Viral proteins function as ion channels
title_full Viral proteins function as ion channels
title_fullStr Viral proteins function as ion channels
title_full_unstemmed Viral proteins function as ion channels
title_short Viral proteins function as ion channels
title_sort viral proteins function as ion channels
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094589/
https://www.ncbi.nlm.nih.gov/pubmed/20478263
http://dx.doi.org/10.1016/j.bbamem.2010.05.006
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AT xieshiqi viralproteinsfunctionasionchannels
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