Large-scale production and purification of VLP-based vaccines

Virus-like particles (VLPs) hold tremendous potential as vaccine candidates. These innovative biopharmaceuticals present the remarkable advantages of closely mimicking the three-dimensional nature of an actual virus while lacking the virus genome packaged inside its capsid. As a result, an equally e...

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Detalles Bibliográficos
Autores principales: Vicente, Tiago, Roldão, António, Peixoto, Cristina, Carrondo, Manuel J.T., Alves, Paula M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094596/
https://www.ncbi.nlm.nih.gov/pubmed/21784230
http://dx.doi.org/10.1016/j.jip.2011.05.004
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author Vicente, Tiago
Roldão, António
Peixoto, Cristina
Carrondo, Manuel J.T.
Alves, Paula M.
author_facet Vicente, Tiago
Roldão, António
Peixoto, Cristina
Carrondo, Manuel J.T.
Alves, Paula M.
author_sort Vicente, Tiago
collection PubMed
description Virus-like particles (VLPs) hold tremendous potential as vaccine candidates. These innovative biopharmaceuticals present the remarkable advantages of closely mimicking the three-dimensional nature of an actual virus while lacking the virus genome packaged inside its capsid. As a result, an equally efficient but safer prophylaxis is anticipated as compared to inactivated or live attenuated viral vaccines. With the advent of successful cases of approved VLP-based vaccines, pharmaceutical companies are indeed redirecting their resources to the development of such products. This paper reviews the current choices and trends of large-scale production and purification of VLP-based vaccines generated through the baculovirus expression vector system using insect cells.
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spelling pubmed-70945962020-03-25 Large-scale production and purification of VLP-based vaccines Vicente, Tiago Roldão, António Peixoto, Cristina Carrondo, Manuel J.T. Alves, Paula M. J Invertebr Pathol Article Virus-like particles (VLPs) hold tremendous potential as vaccine candidates. These innovative biopharmaceuticals present the remarkable advantages of closely mimicking the three-dimensional nature of an actual virus while lacking the virus genome packaged inside its capsid. As a result, an equally efficient but safer prophylaxis is anticipated as compared to inactivated or live attenuated viral vaccines. With the advent of successful cases of approved VLP-based vaccines, pharmaceutical companies are indeed redirecting their resources to the development of such products. This paper reviews the current choices and trends of large-scale production and purification of VLP-based vaccines generated through the baculovirus expression vector system using insect cells. Elsevier Inc. 2011-07 2011-07-22 /pmc/articles/PMC7094596/ /pubmed/21784230 http://dx.doi.org/10.1016/j.jip.2011.05.004 Text en Copyright © 2011 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Vicente, Tiago
Roldão, António
Peixoto, Cristina
Carrondo, Manuel J.T.
Alves, Paula M.
Large-scale production and purification of VLP-based vaccines
title Large-scale production and purification of VLP-based vaccines
title_full Large-scale production and purification of VLP-based vaccines
title_fullStr Large-scale production and purification of VLP-based vaccines
title_full_unstemmed Large-scale production and purification of VLP-based vaccines
title_short Large-scale production and purification of VLP-based vaccines
title_sort large-scale production and purification of vlp-based vaccines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094596/
https://www.ncbi.nlm.nih.gov/pubmed/21784230
http://dx.doi.org/10.1016/j.jip.2011.05.004
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