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Virus Entry: Looking Back and Moving Forward
Research over a period of more than half a century has provided a reasonably accurate picture of mechanisms involved in animal virus entry into their host cells. Successive steps in entry include binding to receptors, endocytosis, passage through one or more membranes, targeting to specific sites wi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Published by Elsevier Ltd.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094621/ https://www.ncbi.nlm.nih.gov/pubmed/29709571 http://dx.doi.org/10.1016/j.jmb.2018.03.034 |
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author | Helenius, Ari |
author_facet | Helenius, Ari |
author_sort | Helenius, Ari |
collection | PubMed |
description | Research over a period of more than half a century has provided a reasonably accurate picture of mechanisms involved in animal virus entry into their host cells. Successive steps in entry include binding to receptors, endocytosis, passage through one or more membranes, targeting to specific sites within the cell, and uncoating of the genome. For some viruses, the molecular interactions are known in great detail. However, as more viruses are analyzed, and as the focus shifts from tissue culture to in vivo experiments, it is evident that viruses display considerable redundancy and flexibility in receptor usage, endocytic mechanism, location of penetration, and uncoating mechanism. For many viruses, the picture is still elusive because the interactions that they engage in rely on sophisticated adaptation to complex cellular functions and defense mechanisms. |
format | Online Article Text |
id | pubmed-7094621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70946212020-03-25 Virus Entry: Looking Back and Moving Forward Helenius, Ari J Mol Biol Article Research over a period of more than half a century has provided a reasonably accurate picture of mechanisms involved in animal virus entry into their host cells. Successive steps in entry include binding to receptors, endocytosis, passage through one or more membranes, targeting to specific sites within the cell, and uncoating of the genome. For some viruses, the molecular interactions are known in great detail. However, as more viruses are analyzed, and as the focus shifts from tissue culture to in vivo experiments, it is evident that viruses display considerable redundancy and flexibility in receptor usage, endocytic mechanism, location of penetration, and uncoating mechanism. For many viruses, the picture is still elusive because the interactions that they engage in rely on sophisticated adaptation to complex cellular functions and defense mechanisms. Published by Elsevier Ltd. 2018-06-22 2018-04-28 /pmc/articles/PMC7094621/ /pubmed/29709571 http://dx.doi.org/10.1016/j.jmb.2018.03.034 Text en © 2018 Published by Elsevier Ltd. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Helenius, Ari Virus Entry: Looking Back and Moving Forward |
title | Virus Entry: Looking Back and Moving Forward |
title_full | Virus Entry: Looking Back and Moving Forward |
title_fullStr | Virus Entry: Looking Back and Moving Forward |
title_full_unstemmed | Virus Entry: Looking Back and Moving Forward |
title_short | Virus Entry: Looking Back and Moving Forward |
title_sort | virus entry: looking back and moving forward |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094621/ https://www.ncbi.nlm.nih.gov/pubmed/29709571 http://dx.doi.org/10.1016/j.jmb.2018.03.034 |
work_keys_str_mv | AT heleniusari virusentrylookingbackandmovingforward |