An adenoviral vector-based mucosal vaccine is effective in protection against botulism

A replication-incompetent adenoviral vector encoding the heavy chain C-fragment (H(C)50) of botulinum neurotoxin type C (BoNT/C) was evaluated as a mucosal vaccine against botulism in a mouse model. Single intranasal inoculation of the adenoviral vector elicited a high level of H(C)50-specific IgG,...

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Detalles Bibliográficos
Autores principales: Xu, Q, Pichichero, M E, Simpson, L L, Elias, Md, Smith, L A, Zeng, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094725/
https://www.ncbi.nlm.nih.gov/pubmed/19129860
http://dx.doi.org/10.1038/gt.2008.181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094725/
https://www.ncbi.nlm.nih.gov/pubmed/19129860
http://dx.doi.org/10.1038/gt.2008.181

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