The therapeutic potential of RNA interference

In recent years, we have witnessed the discovery of a new mechanism of gene regulation called RNA interference (RNAi), which has revitalized interest in the development of nucleic acid‐based technologies for therapeutic gene suppression. This review focuses on the potential therapeutic use of RNAi,...

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Detalles Bibliográficos
Autor principal: Uprichard, Susan L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2005
Materias:
Minireviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094730/
https://www.ncbi.nlm.nih.gov/pubmed/16115631
http://dx.doi.org/10.1016/j.febslet.2005.08.004
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author Uprichard, Susan L.
author_facet Uprichard, Susan L.
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description In recent years, we have witnessed the discovery of a new mechanism of gene regulation called RNA interference (RNAi), which has revitalized interest in the development of nucleic acid‐based technologies for therapeutic gene suppression. This review focuses on the potential therapeutic use of RNAi, discussing the theoretical advantages of RNAi‐based therapeutics over previous technologies as well as the challenges involved in developing RNAi for clinical use. Also reviewed, are the in vivo proof‐of principle experiments that provide the preclinical justification for the continued development of RNAi‐based therapeutics.
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spelling pubmed-70947302020-03-25 The therapeutic potential of RNA interference Uprichard, Susan L. FEBS Lett Minireviews In recent years, we have witnessed the discovery of a new mechanism of gene regulation called RNA interference (RNAi), which has revitalized interest in the development of nucleic acid‐based technologies for therapeutic gene suppression. This review focuses on the potential therapeutic use of RNAi, discussing the theoretical advantages of RNAi‐based therapeutics over previous technologies as well as the challenges involved in developing RNAi for clinical use. Also reviewed, are the in vivo proof‐of principle experiments that provide the preclinical justification for the continued development of RNAi‐based therapeutics. John Wiley and Sons Inc. 2005-10-31 2005-08-15 /pmc/articles/PMC7094730/ /pubmed/16115631 http://dx.doi.org/10.1016/j.febslet.2005.08.004 Text en FEBS Letters 579 (2005) 1873-3468 © 2015 Federation of European Biochemical Societies This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.
spellingShingle Minireviews
Uprichard, Susan L.
The therapeutic potential of RNA interference
title The therapeutic potential of RNA interference
title_full The therapeutic potential of RNA interference
title_fullStr The therapeutic potential of RNA interference
title_full_unstemmed The therapeutic potential of RNA interference
title_short The therapeutic potential of RNA interference
title_sort therapeutic potential of rna interference
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094730/
https://www.ncbi.nlm.nih.gov/pubmed/16115631
http://dx.doi.org/10.1016/j.febslet.2005.08.004
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