Cargando…

Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD

This consensus statement established under the auspices of the German working group on BM and blood stem cell transplantation (DAG-KBT), the German Society of Hematology and Oncology (DGHO), the Austrian Stem Cell Transplant Working Group, the Swiss Blood Stem Cell Transplantation Group (SBST) and t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hildebrandt, G C, Fazekas, T, Lawitschka, A, Bertz, H, Greinix, H, Halter, J, Pavletic, S Z, Holler, E, Wolff, D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094778/
https://www.ncbi.nlm.nih.gov/pubmed/21441964
http://dx.doi.org/10.1038/bmt.2011.35
_version_ 1783510536331198464
author Hildebrandt, G C
Fazekas, T
Lawitschka, A
Bertz, H
Greinix, H
Halter, J
Pavletic, S Z
Holler, E
Wolff, D
author_facet Hildebrandt, G C
Fazekas, T
Lawitschka, A
Bertz, H
Greinix, H
Halter, J
Pavletic, S Z
Holler, E
Wolff, D
author_sort Hildebrandt, G C
collection PubMed
description This consensus statement established under the auspices of the German working group on BM and blood stem cell transplantation (DAG-KBT), the German Society of Hematology and Oncology (DGHO), the Austrian Stem Cell Transplant Working Group, the Swiss Blood Stem Cell Transplantation Group (SBST) and the German-Austrian Pediatric Working Group on SCT (Päd-Ag-KBT) summarizes current evidence for diagnosis, immunosuppressive and supportive therapy to provide practical guidelines for the care and treatment of patients with pulmonary manifestations of chronic GVHD (cGVHD). Pulmonary cGVHD can present with obstructive and/or restrictive changes. Disease severity ranges from subclinical pulmonary function test (PFT) impairment to respiratory insufficiency with bronchiolitis obliterans being the only pulmonary complication currently considered diagnostic of cGVHD. Early diagnosis may improve clinical outcome, and regular post-transplant follow-up PFTs are recommended. Diagnostic work-up includes high-resolution computed tomography, bronchoalveolar lavage and histology. Topical treatment is based on inhalative steroids plus beta-agonists. Early addition of azithromycin is suggested. Systemic first-line treatment consists of corticosteroids plus, if any, continuation of other immunosuppressive therapy. Second-line therapy and beyond includes extracorporeal photopheresis, mammalian target of rapamycin inhibitors, mycophenolate, etanercept, imatinib and TLI, but efficacy is limited. Clinical trials are urgently needed to improve understanding and treatment of this deleterious complication.
format Online
Article
Text
id pubmed-7094778
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-70947782020-03-26 Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD Hildebrandt, G C Fazekas, T Lawitschka, A Bertz, H Greinix, H Halter, J Pavletic, S Z Holler, E Wolff, D Bone Marrow Transplant Article This consensus statement established under the auspices of the German working group on BM and blood stem cell transplantation (DAG-KBT), the German Society of Hematology and Oncology (DGHO), the Austrian Stem Cell Transplant Working Group, the Swiss Blood Stem Cell Transplantation Group (SBST) and the German-Austrian Pediatric Working Group on SCT (Päd-Ag-KBT) summarizes current evidence for diagnosis, immunosuppressive and supportive therapy to provide practical guidelines for the care and treatment of patients with pulmonary manifestations of chronic GVHD (cGVHD). Pulmonary cGVHD can present with obstructive and/or restrictive changes. Disease severity ranges from subclinical pulmonary function test (PFT) impairment to respiratory insufficiency with bronchiolitis obliterans being the only pulmonary complication currently considered diagnostic of cGVHD. Early diagnosis may improve clinical outcome, and regular post-transplant follow-up PFTs are recommended. Diagnostic work-up includes high-resolution computed tomography, bronchoalveolar lavage and histology. Topical treatment is based on inhalative steroids plus beta-agonists. Early addition of azithromycin is suggested. Systemic first-line treatment consists of corticosteroids plus, if any, continuation of other immunosuppressive therapy. Second-line therapy and beyond includes extracorporeal photopheresis, mammalian target of rapamycin inhibitors, mycophenolate, etanercept, imatinib and TLI, but efficacy is limited. Clinical trials are urgently needed to improve understanding and treatment of this deleterious complication. Nature Publishing Group UK 2011-03-28 2011 /pmc/articles/PMC7094778/ /pubmed/21441964 http://dx.doi.org/10.1038/bmt.2011.35 Text en © Macmillan Publishers Limited 2011 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Hildebrandt, G C
Fazekas, T
Lawitschka, A
Bertz, H
Greinix, H
Halter, J
Pavletic, S Z
Holler, E
Wolff, D
Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD
title Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD
title_full Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD
title_fullStr Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD
title_full_unstemmed Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD
title_short Diagnosis and treatment of pulmonary chronic GVHD: report from the consensus conference on clinical practice in chronic GVHD
title_sort diagnosis and treatment of pulmonary chronic gvhd: report from the consensus conference on clinical practice in chronic gvhd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094778/
https://www.ncbi.nlm.nih.gov/pubmed/21441964
http://dx.doi.org/10.1038/bmt.2011.35
work_keys_str_mv AT hildebrandtgc diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT fazekast diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT lawitschkaa diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT bertzh diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT greinixh diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT halterj diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT pavleticsz diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT hollere diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd
AT wolffd diagnosisandtreatmentofpulmonarychronicgvhdreportfromtheconsensusconferenceonclinicalpracticeinchronicgvhd